Inflammatory pain-induced signaling events following a conditional deletion of the N -methyl- d -aspartate receptor in spinal cord dorsal horn

Abstract The N -methyl- d -aspartate (NMDA) receptor in the spinal cord dorsal horn (SCDH) is one of the mechanisms involved in central sensitization during chronic pain. Previously, this laboratory created a spatio-temporal knockout (KO) of the N -methyl- d -aspartate receptor I (NR1) subunit in th...

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Veröffentlicht in:	Neuroscience 2008-08, Vol.155 (3), p.948-958
Hauptverfasser:	Cheng, H.T, Suzuki, M, Hegarty, D.M, Xu, Q, Weyerbacher, A.R, South, S.M, Ohata, M, Inturrisi, C.E
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Biological and medical sciences Cyclooxygenase 2 - metabolism cyclooxygenase-2 Extracellular Signal-Regulated MAP Kinases - metabolism Freund's Adjuvant - adverse effects Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Enzymologic Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Hyperalgesia - physiopathology inflammatory pain Mice Mice, Transgenic mitogen activated protein kinases N-methyl- d-aspartate receptor Neurology p38 Pain - chemically induced Pain - pathology Pain Threshold - physiology Phosphorylation - drug effects Physical Stimulation Posterior Horn Cells - metabolism Protein Kinase C - metabolism protein kinase cγ Receptors, N-Methyl-D-Aspartate - deficiency Signal Transduction - drug effects Signal Transduction - physiology Spinal Cord - pathology Time Factors Vertebrates: nervous system and sense organs
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