Following translation by single ribosomes one codon at a time

We have followed individual ribosomes as they translate single messenger RNA hairpins tethered by the ends to optical tweezers. Here we reveal that translation occurs through successive translocation-and-pause cycles. The distribution of pause lengths, with a median of 2.8 s, indicates that at least...

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Veröffentlicht in:	Nature 2008-04, Vol.452 (7187), p.598-603
Hauptverfasser:	Tinoco, Ignacio, Wen, Jin-Der, Lancaster, Laura, Hodges, Courtney, Zeri, Ana-Carolina, Yoshimura, Shige H, Noller, Harry F, Bustamante, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoacylation Base Pairing Biological and medical sciences Codon - genetics Fundamental and applied biological sciences. Psychology Humanities and Social Sciences Kinetics Molecular and cellular biology Molecular biology Molecular genetics Molecular structure multidisciplinary Optical Tweezers Protein Biosynthesis - physiology Ribonucleic acid Ribosomes - metabolism RNA RNA, Messenger - chemistry RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Transfer - genetics RNA, Transfer - metabolism Science Science (multidisciplinary) Time Factors Translation. Translation factors. Protein processing Translocation
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