Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin

Gamma-secretase is a multiprotein complex composed of presenilin (PS), nicastrin (NCT), Aph-1, and Pen-2, and it catalyzes the final proteolytic step in the processing of amyloid precursor protein to generate amyloid-beta. Our previous results showed that tumor necrosis factor-alpha (TNF-alpha) can...

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Veröffentlicht in:	Molecular biology of the cell 2008-10, Vol.19 (10), p.4201-4212
Hauptverfasser:	Kuo, Lan-Hsin, Hu, Ming-Kuan, Hsu, Wen-Ming, Tung, Ying-Tsen, Wang, Bo-Jeng, Tsai, Wang-Wei, Yen, Chen-Tung, Liao, Yung-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid Precursor Protein Secretases - chemistry Animals Cell Line CHO Cells Cricetinae Cricetulus Enzyme Inhibitors - pharmacology Gene Expression Regulation Membrane Glycoproteins - chemistry Models, Biological Mutation Phosphorylation Presenilins - chemistry Protein Binding Protein Isoforms Tumor Necrosis Factor-alpha - metabolism
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