Structural and functional dissection of Mif2p, a conserved DNA-binding kinetochore protein

Mif2p is the budding-yeast orthologue of the mammalian centromere-binding protein CENP-C. We have mapped domains of Saccharomyces cerevisiae Mif2p and studied the phenotyptic consequences of their deletion. Using chromatin immunoprecipitation (ChIP) and electrophoretic mobility shift assays, we have...

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Veröffentlicht in:	Molecular biology of the cell 2008-10, Vol.19 (10), p.4480-4491
Hauptverfasser:	Cohen, R L, Espelin, C W, De Wulf, P, Sorger, P K, Harrison, S C, Simons, K T
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Crystallography, X-Ray - methods Dimerization DNA-Binding Proteins - chemistry DNA-Binding Proteins - physiology Gene Expression Regulation, Fungal Kinetochores - chemistry Kinetochores - metabolism Molecular Sequence Data Phenotype Protein Binding Protein Structure, Tertiary Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - physiology Saccharomycetales Sequence Homology, Amino Acid
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