2‘-Fluoroarabino- and Arabinonucleic Acid Show Different Conformations, Resulting in Deviating RNA Affinities and Processing of Their Heteroduplexes with RNA by RNase H

2‘-Deoxy-2‘-fluoro-arabinonucleic acid (FANA) and arabinonucleic acid (ANA) paired to RNA are substrates of RNase H. The conformation of the natural DNA/RNA hybrid substrates appears to be neither A-form nor B-form. Consistent with this, the conformations of FANA and ANA were found to be intermediat...

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Veröffentlicht in:	Biochemistry (Easton) 2006-04, Vol.45 (13), p.4141-4152
Hauptverfasser:	Li, Feng, Sarkhel, Sanjay, Wilds, Christopher J, Wawrzak, Zdzislaw, Prakash, Thazha P, Manoharan, Muthiah, Egli, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Arabinonucleotides - chemistry Arabinonucleotides - metabolism Nucleic Acid Conformation Nucleic Acid Heteroduplexes - metabolism Ribonuclease H - metabolism
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