Displacement of α-Actinin from the NMDA Receptor NR1 C0 Domain By Ca2+/Calmodulin Promotes CaMKII Binding

Ca2+ influx through the N-methyl-d-aspartate (NMDA)-type glutamate receptor triggers activation and postsynaptic accumulation of Ca2+/calmodulin-dependent kinase II (CaMKII). CaMKII, calmodulin, and α-actinin directly bind to the short membrane proximal C0 domain of the C-terminal region of the NMDA...

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Veröffentlicht in:	Biochemistry (Easton) 2007-07, Vol.46 (29), p.8485-8497
Hauptverfasser:	Merrill, Michelle A, Malik, Zulfiqar, Akyol, Zeynep, Bartos, Jason A, Leonard, A. Soren, Hudmon, Andy, Shea, Madeline A, Hell, Johannes W
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinin - metabolism Animals Binding Sites Calcium - metabolism Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases - metabolism Calmodulin - metabolism Humans Protein Structure, Tertiary Rats Receptors, N-Methyl-D-Aspartate - chemistry Receptors, N-Methyl-D-Aspartate - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Signal Transduction
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