Induced Fit Conformational Changes of a “Reversed Amidine” Heterocycle:  Optimized Interactions in a DNA Minor Groove Complex

To better understand the molecular basis for recognition of the DNA minor groove by heterocyclic cations, a series of “reversed amidine” substituted heterocycles has been prepared. Amidine derivatives for targeting the minor groove have the amidine carbon linked to a central heterocyclic system, whe...

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