Exogenous zinc protects cardiac cells from reperfusion injury by targeting mitochondrial permeability transition pore through inactivation of glycogen synthase kinase-3β

The purpose of this study was to determine whether exogenous zinc prevents cardiac reperfusion injury by targeting the mitochondrial permeability transition pore (mPTP) via glycogen synthase kinase-3β (GSK-3β). The treatment of cardiac H9c2 cells with ZnCl 2 (10 μM) in the presence of zinc ionophore...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2008-09, Vol.295 (3), p.H1227-H1233
Hauptverfasser:	Chanoit, Guillaume, Lee, SungRyul, Xi, Jinkun, Zhu, Min, McIntosh, Rachel A., Mueller, Robert A., Norfleet, Edward A., Xu, Zhelong
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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