Orientation and structure of the Ndc80 complex on the microtubule lattice

The four-subunit Ndc80 complex, comprised of Ndc80/Nuf2 and Spc24/Spc25 dimers, directly connects kinetochores to spindle microtubules. The complex is anchored to the kinetochore at the Spc24/25 end, and the Ndc80/Nuf2 dimer projects outward to bind to microtubules. Here, we use cryoelectron microsc...

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Veröffentlicht in:	The Journal of cell biology 2008-09, Vol.182 (6), p.1055-1061
Hauptverfasser:	Wilson-Kubalek, Elizabeth M, Cheeseman, Iain M, Yoshioka, Craig, Desai, Arshad, Milligan, Ronald A
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Biochemistry Cell Cycle Proteins - chemistry Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cells Cooperation Cryoelectron Microscopy Crystal lattices Crystal structure Crystallography, X-Ray Dimerization Dimers Electron microscopes Humans Image analysis Kinetochores Kinetochores - metabolism Microscopy Microtubules Microtubules - metabolism Microtubules - ultrastructure Models, Molecular Molecular Sequence Data Monomers Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Conformation Protein Subunits - genetics Protein Subunits - metabolism Proteins Spindle Apparatus - metabolism Spindle Apparatus - ultrastructure
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