N-acetylcysteine protects against renal injury following bilateral ureteral obstruction

Background. Obstructive nephropathy decreases renal blood flow (RBF) and glomerular filtration rate (GFR), causing tubular abnormalities, such as urinary concentrating defect, as well as increasing oxidative stress. This study aimed to evaluate the effects of N-acetylcysteine (NAC) on renal function...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2008-10, Vol.23 (10), p.3067-3073
Hauptverfasser:	Shimizu, Maria Heloisa Massola, Danilovic, Alexandre, Andrade, Lucia, Volpini, Rildo A., Libório, Alexandre B., Sanches, Talita R.C., Seguro, Antonio Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals aquaporin 2 Aquaporin 2 - metabolism bilateral ureteral obstruction Biological and medical sciences Emergency and intensive care: renal failure. Dialysis management endothelial nitric oxide synthase Experimental Nephrology Glomerular Filtration Rate - drug effects Intensive care medicine inulin clearance Kidney - drug effects Kidney - pathology Kidney - physiopathology Kidney Diseases - etiology Kidney Diseases - pathology Kidney Diseases - physiopathology Kidney Diseases - prevention & control Lipid Peroxidation - drug effects Male Medical sciences N-acetylcysteine Nitric Oxide Synthase Type III - metabolism Osmolar Concentration Rats Rats, Wistar Renal Circulation - drug effects Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system Thiobarbituric Acid Reactive Substances - metabolism Ureteral Obstruction - complications Ureteral Obstruction - drug therapy Ureteral Obstruction - physiopathology Urine - chemistry
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