Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal

Transient receptor potential (TRP) A1 channels are cation channels found preferentially on nociceptive sensory neurones, including capsaicin-sensitive TRPV1-expressing vagal bronchopulmonary C-fibres, and are activated by electrophilic compounds such as mustard oil and cinnamaldehyde. Oxidative stre...

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Veröffentlicht in:	The Journal of physiology 2008-07, Vol.586 (14), p.3447-3459
Hauptverfasser:	Taylor‐Clark, T. E., McAlexander, M. A., Nassenstein, C., Sheardown, S. A., Wilson, S., Thornton, J., Carr, M. J., Undem, B. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Aldehydes - pharmacology Animals Autacoids - pharmacology Calcium - metabolism Calcium Channels - genetics Calcium Channels - metabolism Capsaicin - pharmacology Cell Line Dose-Response Relationship, Drug Endothelial Cells - metabolism Guinea Pigs Humans Lung - innervation Mice Mice, Knockout Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons, Afferent - drug effects Neurons, Afferent - physiology Neuroscience Transient Receptor Potential Channels - genetics Transient Receptor Potential Channels - metabolism TRPA1 Cation Channel TRPV Cation Channels - genetics TRPV Cation Channels - metabolism Vagus Nerve - physiology
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