The HER4/4ICD estrogen receptor coactivator and BH3-only protein is an effector of tamoxifen-induced apoptosis

Greater than 40% of breast cancer patients treated with tamoxifen exhibit de novo or acquired tumor resistance. Recent clinical evidence indicates that loss of expression of HER4 is an independent marker for tamoxifen resistance. In direct corroboration with clinical observations, suppression of HER...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2008-08, Vol.68 (15), p.6387-6395
Hauptverfasser:	Naresh, Anjali, Thor, Ann D, Edgerton, Susan M, Torkko, Kathleen C, Kumar, Rakesh, Jones, Frank E
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Hormonal - pharmacology Apoptosis - drug effects Breast Neoplasms - pathology Cell Line, Tumor Humans Immunohistochemistry Mitochondria - metabolism Proto-Oncogene Proteins - metabolism Receptors, Estrogen - agonists Tamoxifen - pharmacology Transcription Factors - metabolism
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