Gentamicin is primarily localized in vestibular type I hair cells after intratympanic administration

Intratympanic (IT) gentamicin injections are effective in the control of episodic vertigo due to Ménière's disease. Histological studies in animals have found that the loss of type I vestibular hair cells far exceeds that of type II cells after IT gentamicin treatment. The objective of this stu...

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Veröffentlicht in:	Journal of the Association for Research in Otolaryngology 2007-12, Vol.8 (4), p.497-508
Hauptverfasser:	Lyford-Pike, Sofia, Vogelheim, Casey, Chu, Eugene, Della Santina, Charles C, Carey, John P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacokinetics Chinchilla Gentamicins - administration & dosage Gentamicins - pharmacokinetics Gentamicins - toxicity Hair Cells, Vestibular - drug effects Hair Cells, Vestibular - metabolism Humans Immunohistochemistry Tympanic Membrane - drug effects Xanthenes - metabolism
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