Amino acid sequence requirements of the transmembrane and cytoplasmic domains of influenza virus hemagglutinin for viable membrane fusion

The amino acid sequence requirements of the transmembrane (TM) domain and cytoplasmic tail (CT) of the hemagglutinin (HA) of influenza virus in membrane fusion have been investigated. Fusion properties of wild-type HA were compared with those of chimeras consisting of the ectodomain of HA and the TM...

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Veröffentlicht in:	Molecular biology of the cell 1999-06, Vol.10 (6), p.1821-1836
Hauptverfasser:	Melikyan, G B, Lin, S, Roth, M G, Cohen, F S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Cell Membrane Cytoplasm Erythrocytes - metabolism Erythrocytes - virology Hemagglutinin Glycoproteins, Influenza Virus - chemistry Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - metabolism Humans Kinetics Membrane Fusion - physiology Molecular Sequence Data Point Mutation Protein Folding Recombinant Proteins - genetics Recombinant Proteins - metabolism
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