The management of pulmonary hypertension in children
Pulmonary hypertension is relatively common in children and has many causes. The management of the condition has changed dramatically in the past 5 years with the introduction of new medicines. However, diagnosis, investigation and choice of therapy remain a challenge. In 2002 the United Kingdom Pul...
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| Veröffentlicht in: | Archives of disease in childhood 2008-07, Vol.93 (7), p.620-625 |
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| creator | Haworth, S G |
| description | Pulmonary hypertension is relatively common in children and has many causes. The management of the condition has changed dramatically in the past 5 years with the introduction of new medicines. However, diagnosis, investigation and choice of therapy remain a challenge. In 2002 the United Kingdom Pulmonary Hypertension Service for Children was established and this has become the mainstay of management in this country. This service, based at Great Ormond Street Hospital for Children, provides advice, expertise and infrastructure support for the most severely affected patients, particularly those with idiopathic pulmonary arterial hypertension for whom chronic intravenous prostacyclin remains the most effective medication. New medicines are being developed which, rather than focussing on dilating a diseased pulmonary vascular bed, aim to structurally remodel the pulmonary vasculature towards normal. |
| doi_str_mv | 10.1136/adc.2007.120493 |
| format | Article |
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The management of the condition has changed dramatically in the past 5 years with the introduction of new medicines. However, diagnosis, investigation and choice of therapy remain a challenge. In 2002 the United Kingdom Pulmonary Hypertension Service for Children was established and this has become the mainstay of management in this country. This service, based at Great Ormond Street Hospital for Children, provides advice, expertise and infrastructure support for the most severely affected patients, particularly those with idiopathic pulmonary arterial hypertension for whom chronic intravenous prostacyclin remains the most effective medication. New medicines are being developed which, rather than focussing on dilating a diseased pulmonary vascular bed, aim to structurally remodel the pulmonary vasculature towards normal.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/adc.2007.120493</identifier><identifier>PMID: 18381346</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Adults ; Antihypertensive Agents - therapeutic use ; Biological and medical sciences ; Bone marrow ; Cardiac Catheterization ; Cardiovascular disease ; Care and treatment ; Child ; Children ; Children & youth ; Chronic illnesses ; Classification ; Congenital diseases ; Demographic aspects ; Diseases ; Drugs ; Evidence ; Families & family life ; Flow velocity ; General aspects ; Heart failure ; Hospice care ; Humans ; Hypertension ; Hypertension, Pulmonary - classification ; Hypertension, Pulmonary - diagnosis ; Hypertension, Pulmonary - etiology ; Hypertension, Pulmonary - therapy ; Lung diseases ; Medical sciences ; Miscellaneous ; Narcotics ; Patient Selection ; Pediatric diseases ; Pneumology ; Prevention and actions ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Pulmonary arteries ; Pulmonary hypertension ; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. 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The management of the condition has changed dramatically in the past 5 years with the introduction of new medicines. However, diagnosis, investigation and choice of therapy remain a challenge. In 2002 the United Kingdom Pulmonary Hypertension Service for Children was established and this has become the mainstay of management in this country. This service, based at Great Ormond Street Hospital for Children, provides advice, expertise and infrastructure support for the most severely affected patients, particularly those with idiopathic pulmonary arterial hypertension for whom chronic intravenous prostacyclin remains the most effective medication. New medicines are being developed which, rather than focussing on dilating a diseased pulmonary vascular bed, aim to structurally remodel the pulmonary vasculature towards normal.</description><subject>Adults</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Cardiac Catheterization</subject><subject>Cardiovascular disease</subject><subject>Care and treatment</subject><subject>Child</subject><subject>Children</subject><subject>Children & youth</subject><subject>Chronic illnesses</subject><subject>Classification</subject><subject>Congenital diseases</subject><subject>Demographic aspects</subject><subject>Diseases</subject><subject>Drugs</subject><subject>Evidence</subject><subject>Families & family life</subject><subject>Flow velocity</subject><subject>General aspects</subject><subject>Heart failure</subject><subject>Hospice care</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension, Pulmonary - classification</subject><subject>Hypertension, Pulmonary - diagnosis</subject><subject>Hypertension, Pulmonary - etiology</subject><subject>Hypertension, Pulmonary - therapy</subject><subject>Lung diseases</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Narcotics</subject><subject>Patient Selection</subject><subject>Pediatric diseases</subject><subject>Pneumology</subject><subject>Prevention and actions</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Pulmonary arteries</subject><subject>Pulmonary hypertension</subject><subject>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. 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Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Pulmonary arteries</topic><topic>Pulmonary hypertension</topic><topic>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</topic><topic>Quality of Life</topic><topic>Reviews</topic><topic>Young Children</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haworth, S G</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Education Periodicals</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haworth, S G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The management of pulmonary hypertension in children</atitle><jtitle>Archives of disease in childhood</jtitle><addtitle>Arch Dis Child</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>93</volume><issue>7</issue><spage>620</spage><epage>625</epage><pages>620-625</pages><issn>0003-9888</issn><eissn>1468-2044</eissn><coden>ADCHAK</coden><abstract>Pulmonary hypertension is relatively common in children and has many causes. The management of the condition has changed dramatically in the past 5 years with the introduction of new medicines. However, diagnosis, investigation and choice of therapy remain a challenge. In 2002 the United Kingdom Pulmonary Hypertension Service for Children was established and this has become the mainstay of management in this country. This service, based at Great Ormond Street Hospital for Children, provides advice, expertise and infrastructure support for the most severely affected patients, particularly those with idiopathic pulmonary arterial hypertension for whom chronic intravenous prostacyclin remains the most effective medication. New medicines are being developed which, rather than focussing on dilating a diseased pulmonary vascular bed, aim to structurally remodel the pulmonary vasculature towards normal.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>18381346</pmid><doi>10.1136/adc.2007.120493</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0003-9888 |
| ispartof | Archives of disease in childhood, 2008-07, Vol.93 (7), p.620-625 |
| issn | 0003-9888 1468-2044 |
| language | eng |
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| source | MEDLINE; BMJ Journals - NESLi2 |
| subjects | Adults Antihypertensive Agents - therapeutic use Biological and medical sciences Bone marrow Cardiac Catheterization Cardiovascular disease Care and treatment Child Children Children & youth Chronic illnesses Classification Congenital diseases Demographic aspects Diseases Drugs Evidence Families & family life Flow velocity General aspects Heart failure Hospice care Humans Hypertension Hypertension, Pulmonary - classification Hypertension, Pulmonary - diagnosis Hypertension, Pulmonary - etiology Hypertension, Pulmonary - therapy Lung diseases Medical sciences Miscellaneous Narcotics Patient Selection Pediatric diseases Pneumology Prevention and actions Public health. Hygiene Public health. Hygiene-occupational medicine Pulmonary arteries Pulmonary hypertension Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Quality of Life Reviews Young Children |
| title | The management of pulmonary hypertension in children |
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