The association of membrane frizzled-related protein (MFRP) gene with acute angle-closure glaucoma--a pilot study

The membrane frizzled-related protein (MFRP) has been proposed as a probable candidate gene for extreme hyperopia and nanophthalmos, which are factors for angle-closure glaucoma. The purpose of our study was to investigate whether there are significant associations between angle-closure glaucoma and...

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Veröffentlicht in:	Molecular vision 2008-09, Vol.14, p.1673-1679
Hauptverfasser:	Wang, I-Jong, Lin, Shan, Chiang, Ting-Hsuan, Chen, Zoe Tzu-Yi, Lin, Luke L K, Hung, Por-Tying, Shih, Yung-Feng
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Sprache:	eng
Schlagworte:	Case-Control Studies Female Genetic Predisposition to Disease Glaucoma, Angle-Closure - genetics Haplotypes Humans Linkage Disequilibrium - genetics Male Membrane Proteins - genetics Middle Aged Pilot Projects Polymorphism, Single Nucleotide - genetics Sequence Analysis, DNA
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creator	Wang, I-Jong Lin, Shan Chiang, Ting-Hsuan Chen, Zoe Tzu-Yi Lin, Luke L K Hung, Por-Tying Shih, Yung-Feng
description	The membrane frizzled-related protein (MFRP) has been proposed as a probable candidate gene for extreme hyperopia and nanophthalmos, which are factors for angle-closure glaucoma. The purpose of our study was to investigate whether there are significant associations between angle-closure glaucoma and sequence variants in the MFRP gene reported previously in Taiwanese subjects. Genomic DNA was collected from 63 subjects with angle-closure glaucoma and 66 age-matched and gender-matched controls without angle-closure glaucoma. Three sequence variants were detected by polymerase chain reaction (PCR) and direct sequencing in all of the cases and controls. None of the three sequence variants showed a significant result in terms of association with disease. The pairwise linkage disequilibrium (LD) mapping confirmed that these alleles have a comparatively strong LD index greater than 0.7 for D' and greater than 0.4 for r(2) at these polymorphisms. However, we found there were no statistical associations between any of the three sequence variants located on MFRP and angle-closure glaucoma. In our pilot study, variations that we tested in MFRP were not associated with the development of acute angle-closure glaucoma in Taiwanese subjects.
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The purpose of our study was to investigate whether there are significant associations between angle-closure glaucoma and sequence variants in the MFRP gene reported previously in Taiwanese subjects. Genomic DNA was collected from 63 subjects with angle-closure glaucoma and 66 age-matched and gender-matched controls without angle-closure glaucoma. Three sequence variants were detected by polymerase chain reaction (PCR) and direct sequencing in all of the cases and controls. None of the three sequence variants showed a significant result in terms of association with disease. The pairwise linkage disequilibrium (LD) mapping confirmed that these alleles have a comparatively strong LD index greater than 0.7 for D' and greater than 0.4 for r(2) at these polymorphisms. However, we found there were no statistical associations between any of the three sequence variants located on MFRP and angle-closure glaucoma. In our pilot study, variations that we tested in MFRP were not associated with the development of acute angle-closure glaucoma in Taiwanese subjects.</description><identifier>EISSN: 1090-0535</identifier><identifier>PMID: 18781223</identifier><language>eng</language><publisher>United States: Molecular Vision</publisher><subject>Case-Control Studies ; Female ; Genetic Predisposition to Disease ; Glaucoma, Angle-Closure - genetics ; Haplotypes ; Humans ; Linkage Disequilibrium - genetics ; Male ; Membrane Proteins - genetics ; Middle Aged ; Pilot Projects ; Polymorphism, Single Nucleotide - genetics ; Sequence Analysis, DNA</subject><ispartof>Molecular vision, 2008-09, Vol.14, p.1673-1679</ispartof><rights>2008 Molecular Vision</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532703/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532703/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18781223$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, I-Jong</creatorcontrib><creatorcontrib>Lin, Shan</creatorcontrib><creatorcontrib>Chiang, Ting-Hsuan</creatorcontrib><creatorcontrib>Chen, Zoe Tzu-Yi</creatorcontrib><creatorcontrib>Lin, Luke L K</creatorcontrib><creatorcontrib>Hung, Por-Tying</creatorcontrib><creatorcontrib>Shih, Yung-Feng</creatorcontrib><title>The association of membrane frizzled-related protein (MFRP) gene with acute angle-closure glaucoma--a pilot study</title><title>Molecular vision</title><addtitle>Mol Vis</addtitle><description>The membrane frizzled-related protein (MFRP) has been proposed as a probable candidate gene for extreme hyperopia and nanophthalmos, which are factors for angle-closure glaucoma. The purpose of our study was to investigate whether there are significant associations between angle-closure glaucoma and sequence variants in the MFRP gene reported previously in Taiwanese subjects. Genomic DNA was collected from 63 subjects with angle-closure glaucoma and 66 age-matched and gender-matched controls without angle-closure glaucoma. Three sequence variants were detected by polymerase chain reaction (PCR) and direct sequencing in all of the cases and controls. None of the three sequence variants showed a significant result in terms of association with disease. The pairwise linkage disequilibrium (LD) mapping confirmed that these alleles have a comparatively strong LD index greater than 0.7 for D' and greater than 0.4 for r(2) at these polymorphisms. However, we found there were no statistical associations between any of the three sequence variants located on MFRP and angle-closure glaucoma. In our pilot study, variations that we tested in MFRP were not associated with the development of acute angle-closure glaucoma in Taiwanese subjects.</description><subject>Case-Control Studies</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Glaucoma, Angle-Closure - genetics</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Linkage Disequilibrium - genetics</subject><subject>Male</subject><subject>Membrane Proteins - genetics</subject><subject>Middle Aged</subject><subject>Pilot Projects</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Sequence Analysis, DNA</subject><issn>1090-0535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpV0F9LwzAUBfAgiJvTryB51IdAmqTt-iLIcE6YKDKfy21y20XSpqapsn16B_5Bn-7DOef3cI_INOEFZzyV6YScDsMr5yJJVX5CJsk8nydCyCl522yRwjB4bSFa31Ff0xbbKkCHtA52v3doWEAHEQ3tg49oO3r5sHx-uqINHkofNm4p6DEenK5xyLTzwxiQNg5G7VtgDGhvnY90iKPZnZHjGtyA5993Rl6Wt5vFiq0f7-4XN2vWCykjq03OeaG1NnWGWWYKxUGByiHlmCCqLK2E4kXBi7kWWtSIKERllMoUVJXO5Ixcf7n9WLVoNHYxgCv7YFsIu9KDLf8nnd2WjX8vRSpFzuUBuPgL_C5_nic_AQRHbcY</recordid><startdate>20080908</startdate><enddate>20080908</enddate><creator>Wang, I-Jong</creator><creator>Lin, Shan</creator><creator>Chiang, Ting-Hsuan</creator><creator>Chen, Zoe Tzu-Yi</creator><creator>Lin, Luke L K</creator><creator>Hung, Por-Tying</creator><creator>Shih, Yung-Feng</creator><general>Molecular Vision</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>5PM</scope></search><sort><creationdate>20080908</creationdate><title>The association of membrane frizzled-related protein (MFRP) gene with acute angle-closure glaucoma--a pilot study</title><author>Wang, I-Jong ; Lin, Shan ; Chiang, Ting-Hsuan ; Chen, Zoe Tzu-Yi ; Lin, Luke L K ; Hung, Por-Tying ; Shih, Yung-Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p233t-fd7009cccdf6e66d940a4a47a50e1ee465b24099098c2c2feee22bd4464abbc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Case-Control Studies</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Glaucoma, Angle-Closure - genetics</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Linkage Disequilibrium - genetics</topic><topic>Male</topic><topic>Membrane Proteins - genetics</topic><topic>Middle Aged</topic><topic>Pilot Projects</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Sequence Analysis, DNA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, I-Jong</creatorcontrib><creatorcontrib>Lin, Shan</creatorcontrib><creatorcontrib>Chiang, Ting-Hsuan</creatorcontrib><creatorcontrib>Chen, Zoe Tzu-Yi</creatorcontrib><creatorcontrib>Lin, Luke L K</creatorcontrib><creatorcontrib>Hung, Por-Tying</creatorcontrib><creatorcontrib>Shih, Yung-Feng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular vision</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, I-Jong</au><au>Lin, Shan</au><au>Chiang, Ting-Hsuan</au><au>Chen, Zoe Tzu-Yi</au><au>Lin, Luke L K</au><au>Hung, Por-Tying</au><au>Shih, Yung-Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association of membrane frizzled-related protein (MFRP) gene with acute angle-closure glaucoma--a pilot study</atitle><jtitle>Molecular vision</jtitle><addtitle>Mol Vis</addtitle><date>2008-09-08</date><risdate>2008</risdate><volume>14</volume><spage>1673</spage><epage>1679</epage><pages>1673-1679</pages><eissn>1090-0535</eissn><abstract>The membrane frizzled-related protein (MFRP) has been proposed as a probable candidate gene for extreme hyperopia and nanophthalmos, which are factors for angle-closure glaucoma. The purpose of our study was to investigate whether there are significant associations between angle-closure glaucoma and sequence variants in the MFRP gene reported previously in Taiwanese subjects. Genomic DNA was collected from 63 subjects with angle-closure glaucoma and 66 age-matched and gender-matched controls without angle-closure glaucoma. Three sequence variants were detected by polymerase chain reaction (PCR) and direct sequencing in all of the cases and controls. None of the three sequence variants showed a significant result in terms of association with disease. The pairwise linkage disequilibrium (LD) mapping confirmed that these alleles have a comparatively strong LD index greater than 0.7 for D' and greater than 0.4 for r(2) at these polymorphisms. However, we found there were no statistical associations between any of the three sequence variants located on MFRP and angle-closure glaucoma. In our pilot study, variations that we tested in MFRP were not associated with the development of acute angle-closure glaucoma in Taiwanese subjects.</abstract><cop>United States</cop><pub>Molecular Vision</pub><pmid>18781223</pmid><tpages>7</tpages><oa>free_for_read</oa></addata></record>
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subjects	Case-Control Studies Female Genetic Predisposition to Disease Glaucoma, Angle-Closure - genetics Haplotypes Humans Linkage Disequilibrium - genetics Male Membrane Proteins - genetics Middle Aged Pilot Projects Polymorphism, Single Nucleotide - genetics Sequence Analysis, DNA
title	The association of membrane frizzled-related protein (MFRP) gene with acute angle-closure glaucoma--a pilot study
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