Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes

The progression from insulin resistance to type 2 diabetes is caused by the failure of pancreatic beta cells to produce sufficient levels of insulin to meet the metabolic demand. Recent studies indicate that nutrient fluctuations and insulin resistance increase proinsulin synthesis in beta cells bey...

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Veröffentlicht in:	The Journal of clinical investigation 2008-10, Vol.118 (10), p.3378-3389
Hauptverfasser:	Song, Benbo, Scheuner, Donalyn, Ron, David, Pennathur, Subramaniam, Kaufman, Randal J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cell Proliferation Cell Survival - genetics Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - physiopathology Diet Female Gene Deletion Gene Expression Regulation - genetics Insulin-Secreting Cells - cytology Insulin-Secreting Cells - pathology Insulin-Secreting Cells - physiology Lipid Peroxidation Male Mice Mice, Inbred C57BL Mutation Oxidation-Reduction Oxidative Stress - genetics Transcription Factor CHOP - deficiency Transcription Factor CHOP - genetics Transcription Factor CHOP - metabolism
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