Acute effects of two different doses of magnesium sulphate in infants with birth asphyxia
The effects of two different doses of magnesium sulphate (MgSO4) were evaluated in a group of 15 full term infants with Apgar scores of < 6 at 10 minutes, studied within 12 hours of delivery. Seven infants received 400 mg/kg MgSO4 and eight received 250 mg/kg. After the larger dose, mean arterial...
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| Veröffentlicht in: | Archives of disease in childhood. Fetal and neonatal edition 1995-11, Vol.73 (3), p.F174-F177 |
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| container_issue | 3 |
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| container_title | Archives of disease in childhood. Fetal and neonatal edition |
| container_volume | 73 |
| creator | Levene, M. Blennow, M. Whitelaw, A. Hankø, E. Fellman, V. Hartley, R. |
| description | The effects of two different doses of magnesium sulphate (MgSO4) were evaluated in a group of 15 full term infants with Apgar scores of < 6 at 10 minutes, studied within 12 hours of delivery. Seven infants received 400 mg/kg MgSO4 and eight received 250 mg/kg. After the larger dose, mean arterial pressure (MAP) fell by a mean of 6 mm Hg (13%) at one hour but was not significantly reduced thereafter. Respiratory depression lasted three to six hours. EEG readings and heart rate were not significantly different. Mean serum Mg2+ increased from 0.79 to 3.6 mmol/l at one hour. After 250 mg/kg MgSO4, MAP, EEG, tone and heart rate were unchanged. One infant developed transient respiratory depression. Mean serum Mg2+ rose from 0.71 to 2.42 mmol/l at one hour. MgSO4 (400 mg/kg) has an unacceptable risk of hypotension; 250 mg/kg MgSO4 was not associated with hypotension although respiratory depression can occur. |
| doi_str_mv | 10.1136/fn.73.3.F174 |
| format | Article |
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Seven infants received 400 mg/kg MgSO4 and eight received 250 mg/kg. After the larger dose, mean arterial pressure (MAP) fell by a mean of 6 mm Hg (13%) at one hour but was not significantly reduced thereafter. Respiratory depression lasted three to six hours. EEG readings and heart rate were not significantly different. Mean serum Mg2+ increased from 0.79 to 3.6 mmol/l at one hour. After 250 mg/kg MgSO4, MAP, EEG, tone and heart rate were unchanged. One infant developed transient respiratory depression. Mean serum Mg2+ rose from 0.71 to 2.42 mmol/l at one hour. MgSO4 (400 mg/kg) has an unacceptable risk of hypotension; 250 mg/kg MgSO4 was not associated with hypotension although respiratory depression can occur.</description><identifier>ISSN: 1359-2998</identifier><identifier>EISSN: 1468-2052</identifier><identifier>DOI: 10.1136/fn.73.3.F174</identifier><identifier>PMID: 8535876</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Asphyxia Neonatorum - blood ; Asphyxia Neonatorum - drug therapy ; Heart rate ; Humans ; Hypotension - etiology ; Hypoventilation - etiology ; Infant, Newborn ; Infants ; Magnesium - blood ; Magnesium sulfate ; Magnesium Sulfate - pharmacokinetics ; Magnesium Sulfate - therapeutic use ; Sulfates</subject><ispartof>Archives of disease in childhood. 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Fetal and neonatal edition</title><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><description>The effects of two different doses of magnesium sulphate (MgSO4) were evaluated in a group of 15 full term infants with Apgar scores of < 6 at 10 minutes, studied within 12 hours of delivery. Seven infants received 400 mg/kg MgSO4 and eight received 250 mg/kg. After the larger dose, mean arterial pressure (MAP) fell by a mean of 6 mm Hg (13%) at one hour but was not significantly reduced thereafter. Respiratory depression lasted three to six hours. EEG readings and heart rate were not significantly different. Mean serum Mg2+ increased from 0.79 to 3.6 mmol/l at one hour. After 250 mg/kg MgSO4, MAP, EEG, tone and heart rate were unchanged. One infant developed transient respiratory depression. Mean serum Mg2+ rose from 0.71 to 2.42 mmol/l at one hour. MgSO4 (400 mg/kg) has an unacceptable risk of hypotension; 250 mg/kg MgSO4 was not associated with hypotension although respiratory depression can occur.</description><subject>Asphyxia Neonatorum - blood</subject><subject>Asphyxia Neonatorum - drug therapy</subject><subject>Heart rate</subject><subject>Humans</subject><subject>Hypotension - etiology</subject><subject>Hypoventilation - etiology</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Magnesium - blood</subject><subject>Magnesium sulfate</subject><subject>Magnesium Sulfate - pharmacokinetics</subject><subject>Magnesium Sulfate - therapeutic use</subject><subject>Sulfates</subject><issn>1359-2998</issn><issn>1468-2052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcuLFDEQxoMo67p68yo0CHqxxzw6r4uwDK6K6wqiol5CdXeyk7E7GZNud_e_N-MMg3oQQl7frypfqhB6SPCCECaeu7CQbMEWZ0Q2t9AxaYSqKeb0dtkzrmuqtbqL7uW8xhgTKeUROlKccSXFMfp62s2TraxztptyFV01XcWq9-WcbJiqPmb7-3qEy2Czn8cqz8NmBSXIhzIchBJ35adV1fpUZsib1c21h_vojoMh2wf79QR9Onv5cfm6Pn__6s3y9LxumaZNzYsnwgCk64GB60Br6gSRPXBMHQfbCiuo6jCl1gJhnbYNJb0kAiSRCtgJerHLu5nb0fZdcZ1gMJvkR0g3JoI3fyvBr8xl_Gkop6qRuiR4sk-Q4o_Z5smMPnd2GCDYOGdTKqYaIUkBH_8DruOcQvmcKWXFmBHOttSzHdWlmHOy7mCFYLNtmHHBSGaY2Tas4I_-tH-A9x0qer3TfZ7s9UGG9N0IySQ3F5-X5sPFl2_Lt1qZd4V_uuPbcf3_l38BlBuuLQ</recordid><startdate>19951101</startdate><enddate>19951101</enddate><creator>Levene, M.</creator><creator>Blennow, M.</creator><creator>Whitelaw, A.</creator><creator>Hankø, E.</creator><creator>Fellman, V.</creator><creator>Hartley, R.</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19951101</creationdate><title>Acute effects of two different doses of magnesium sulphate in infants with birth asphyxia</title><author>Levene, M. ; Blennow, M. ; Whitelaw, A. ; Hankø, E. ; Fellman, V. ; Hartley, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b3924-500113aa7fda3afca992f617da502f5aeb6e628c022eea13c9e421d716a7178a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Asphyxia Neonatorum - blood</topic><topic>Asphyxia Neonatorum - drug therapy</topic><topic>Heart rate</topic><topic>Humans</topic><topic>Hypotension - etiology</topic><topic>Hypoventilation - etiology</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Magnesium - blood</topic><topic>Magnesium sulfate</topic><topic>Magnesium Sulfate - pharmacokinetics</topic><topic>Magnesium Sulfate - therapeutic use</topic><topic>Sulfates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levene, M.</creatorcontrib><creatorcontrib>Blennow, M.</creatorcontrib><creatorcontrib>Whitelaw, A.</creatorcontrib><creatorcontrib>Hankø, E.</creatorcontrib><creatorcontrib>Fellman, V.</creatorcontrib><creatorcontrib>Hartley, R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood. Fetal and neonatal edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levene, M.</au><au>Blennow, M.</au><au>Whitelaw, A.</au><au>Hankø, E.</au><au>Fellman, V.</au><au>Hartley, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute effects of two different doses of magnesium sulphate in infants with birth asphyxia</atitle><jtitle>Archives of disease in childhood. Fetal and neonatal edition</jtitle><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><date>1995-11-01</date><risdate>1995</risdate><volume>73</volume><issue>3</issue><spage>F174</spage><epage>F177</epage><pages>F174-F177</pages><issn>1359-2998</issn><eissn>1468-2052</eissn><abstract>The effects of two different doses of magnesium sulphate (MgSO4) were evaluated in a group of 15 full term infants with Apgar scores of < 6 at 10 minutes, studied within 12 hours of delivery. Seven infants received 400 mg/kg MgSO4 and eight received 250 mg/kg. After the larger dose, mean arterial pressure (MAP) fell by a mean of 6 mm Hg (13%) at one hour but was not significantly reduced thereafter. Respiratory depression lasted three to six hours. EEG readings and heart rate were not significantly different. Mean serum Mg2+ increased from 0.79 to 3.6 mmol/l at one hour. After 250 mg/kg MgSO4, MAP, EEG, tone and heart rate were unchanged. One infant developed transient respiratory depression. Mean serum Mg2+ rose from 0.71 to 2.42 mmol/l at one hour. MgSO4 (400 mg/kg) has an unacceptable risk of hypotension; 250 mg/kg MgSO4 was not associated with hypotension although respiratory depression can occur.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>8535876</pmid><doi>10.1136/fn.73.3.F174</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives of disease in childhood. Fetal and neonatal edition, 1995-11, Vol.73 (3), p.F174-F177 |
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| source | MEDLINE; PubMed Central; Alma/SFX Local Collection |
| subjects | Asphyxia Neonatorum - blood Asphyxia Neonatorum - drug therapy Heart rate Humans Hypotension - etiology Hypoventilation - etiology Infant, Newborn Infants Magnesium - blood Magnesium sulfate Magnesium Sulfate - pharmacokinetics Magnesium Sulfate - therapeutic use Sulfates |
| title | Acute effects of two different doses of magnesium sulphate in infants with birth asphyxia |
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