VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma

Little is known about the factors that enable the mobilisation of human mesenchymal stem cells (MSC) from the bone marrow into the blood stream and their recruitment to and retention in the tumour. We found specific migration of MSC towards growth factors present in pancreatic tumours, such as PDGF,...

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Veröffentlicht in:	British journal of cancer 2008-08, Vol.99 (4), p.622-631
Hauptverfasser:	Beckermann, B M, Kallifatidis, G, Groth, A, Frommhold, D, Apel, A, Mattern, J, Salnikov, A V, Moldenhauer, G, Wagner, W, Diehlmann, A, Saffrich, R, Schubert, M, Ho, A D, Giese, N, Büchler, M W, Friess, H, Büchler, P, Herr, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Angiogenesis Angiogenesis Inhibitors - pharmacology Animals Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal, Humanized Antineoplastic Agents - pharmacology Benzamides Bevacizumab Biomedical and Life Sciences Biomedicine Blood vessels Bone marrow Cancer Research Cell Differentiation - drug effects Cell Movement - drug effects Cell Proliferation Cells, Cultured Cetuximab Drug Resistance Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Epidemiology Epidermal growth factor Epidermal Growth Factor - antagonists & inhibitors Epidermal Growth Factor - metabolism Fibroblasts Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Humans Hypotheses Hypoxia Imatinib Mesylate Lentivirus - genetics Male Medical research Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - metabolism Mice Mice, Nude Microscopy Molecular Medicine Muscle, Smooth - cytology Muscle, Smooth - drug effects Muscle, Smooth - metabolism Neovascularization, Pathologic - metabolism Oncology Pancreatic cancer Pancreatic Neoplasms - blood supply Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Piperazines - pharmacology Platelet-Derived Growth Factor - antagonists & inhibitors Platelet-Derived Growth Factor - metabolism Pyrimidines - pharmacology Spheroids, Cellular - pathology Stem cells Surgery Translational Therapeutics Transplantation, Heterologous Tumors Umbilical Veins - cytology Umbilical Veins - drug effects Umbilical Veins - metabolism Vascular endothelial growth factor Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - metabolism
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