Structure−Activity Relationship Analysis of the Selective Inhibition of Transglutaminase 2 by Dihydroisoxazoles

Human transglutaminase 2 (TG2) is believed to play an important role in the pathogenesis of various human disorders including celiac sprue, certain neurological diseases, and some types of cancer. Selective inhibition of TG2 should therefore enable further investigation of its role in physiology and...

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Veröffentlicht in:	Journal of medicinal chemistry 2006-12, Vol.49 (25), p.7493-7501
Hauptverfasser:	Watts, R. Edward, Siegel, Mathew, Khosla, Chaitan
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biological and medical sciences GTP-Binding Proteins - antagonists & inhibitors GTP-Binding Proteins - chemistry Humans Isoxazoles - chemical synthesis Isoxazoles - chemistry Medical sciences Miscellaneous Pharmacology. Drug treatments Stereoisomerism Structure-Activity Relationship Transglutaminases - antagonists & inhibitors Transglutaminases - chemistry
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