IL-17 produced by Paneth cells drives TNF-induced shock

Tumor necrosis factor (TNF) has very potent antitumor activity, but it also provokes a systemic inflammatory response syndrome that leads to shock, organ failure, and death. Here, we demonstrate that interleukin (IL)-17, a proinflammatory cytokine known to be produced mainly by activated T cells, ha...

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Veröffentlicht in:	The Journal of experimental medicine 2008-08, Vol.205 (8), p.1755-1761
Hauptverfasser:	Takahashi, Nozomi, Vanlaere, Ineke, de Rycke, Riet, Cauwels, Anje, Joosten, Leo A B, Lubberts, Erik, van den Berg, Wim B, Libert, Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - administration & dosage Brief Definitive Reports Inflammation Mediators - metabolism Interleukin-17 - antagonists & inhibitors Interleukin-17 - biosynthesis Interleukin-6 - blood Jejunum - drug effects Jejunum - pathology Mice Mice, Inbred C57BL Mice, Knockout Neutralization Tests Nitric Oxide - blood Paneth Cells - drug effects Paneth Cells - pathology Paneth Cells - physiology Rabbits Receptors, Interleukin-17 - deficiency Receptors, Interleukin-17 - genetics Recombinant Proteins - toxicity Shock - etiology Shock - pathology Shock - physiopathology Shock - prevention & control Systemic Inflammatory Response Syndrome - etiology Systemic Inflammatory Response Syndrome - pathology Systemic Inflammatory Response Syndrome - physiopathology Systemic Inflammatory Response Syndrome - prevention & control Tumor Necrosis Factor-alpha - toxicity
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