Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells

Embryonic stem cells (ESCs) could potentially compensate for the lack of blood platelets available for use in transfusions. Here, we describe a new method for generating mouse ESC-derived platelets (ESPs) that can contribute to hemostasis in vivo. Flow cytometric sorting of cells from embryoid bodie...

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Veröffentlicht in:	The Journal of experimental medicine 2008-08, Vol.205 (8), p.1917-1927
Hauptverfasser:	Nishikii, Hidekazu, Eto, Koji, Tamura, Noriko, Hattori, Koichi, Heissig, Beate, Kanaji, Taisuke, Sawaguchi, Akira, Goto, Shinya, Ware, Jerry, Nakauchi, Hiromitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Platelets - cytology Blood Platelets - drug effects Blood Platelets - enzymology Cells, Cultured Dipeptides - pharmacology Embryonic Stem Cells - cytology Embryonic Stem Cells - drug effects Embryonic Stem Cells - enzymology In Vitro Techniques Integrin beta3 - metabolism Megakaryocytes - cytology Megakaryocytes - enzymology Metalloproteases - antagonists & inhibitors Metalloproteases - metabolism Mice Platelet Glycoprotein GPIb-IX Complex - metabolism Platelet Membrane Glycoprotein IIb - metabolism Protease Inhibitors - pharmacology Proto-Oncogene Proteins c-kit - metabolism Thrombopoiesis - drug effects Thrombopoiesis - physiology Thrombosis - etiology
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