Nef modulates the immunogenicity of Gag encoded in a non-infectious HIV DNA vaccine

Abstract Gag-CD8+ T cell responses are associated with immune control of HIV infection. Since during HIV infection Nef impairs T cell responses, we evaluated whether deletion of nef from a non-infectious HIV DNA vaccine (Δ4 Nef(+)), creating Δ5 Nef(−), would affect its immunogenicity. When compared...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2008-07, Vol.26 (31), p.3795-3804
Hauptverfasser:	Arrode, Geraldine, Hegde, Ramakrishna, Jin, Yuhuai, Singh, Dinesh Kumar, Narayan, Opendra, Chebloune, Yahia
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS AIDS Vaccines - immunology Allergy and Immunology Animals Antigens Apoptosis Applied microbiology Biological and medical sciences CD8 T cells CD8-Positive T-Lymphocytes - immunology Cell Death Cell Line Deoxyribonucleic acid DNA DNA vaccine env Gene Products, Human Immunodeficiency Virus - immunology Fundamental and applied biological sciences. Psychology gag Gene Products, Human Immunodeficiency Virus - immunology HIV Human immunodeficiency virus Humans Immune system Immunogenicity Immunology Infections Laboratory animals Life Sciences Lymphocytes Mice Mice, Inbred BALB C Microbiology Miscellaneous Nef nef Gene Products, Human Immunodeficiency Virus - immunology Proteins Studies T cell receptors Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, DNA - immunology Virology Virosomes - biosynthesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!