Platelet glycoprotein Ibα forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF

Arterial blood flow enhances glycoprotein Ibα (GPIbα) binding to vWF, which initiates platelet adhesion to injured vessels. Mutations in the vWF A1 domain that cause type 2B von Willebrand disease (vWD) reduce the flow requirement for adhesion. Here we show that increasing force on GPIbα/vWF bonds f...

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Veröffentlicht in:	The Journal of clinical investigation 2008-09, Vol.118 (9), p.3195-3207
Hauptverfasser:	Yago, Tadayuki, Lou, Jizhong, Wu, Tao, Yang, Jun, Miner, Jonathan J, Coburn, Leslie, Lopez, Jose A, Cruz, Miguel A, Dong, Jing-Fei, McIntire, Larry V, McEver, Rodger P, Zhu, Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Causes of Gene mutations Genetic aspects Health aspects Physiological aspects Von Willebrand factor Von Willebrand's disease
Online-Zugang:	Volltext
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