SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34

Salmonella colonizes a vacuolar niche in host cells during infection. Maturation of the Salmonella-containing vacuole (SCV) involves the formation of phosphatidylinositol 3-phosphate (PI(3)P) on its outer leaflet. SopB, a bacterial virulence factor with phosphoinositide phosphatase activity, was pro...

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Veröffentlicht in:	The Journal of cell biology 2008-08, Vol.182 (4), p.741-752
Hauptverfasser:	Mallo, Gustavo V, Espina, Marianela, Smith, Adam C, Terebiznik, Mauricio R, Alemán, Ainel, Finlay, B. Brett, Rameh, Lucia E, Grinstein, Sergio, Brumell, John H
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Bacterial Proteins - metabolism Bacteriology Biological Transport - drug effects Cell Membrane - drug effects Cell Membrane - enzymology Cell membranes Cell Surface Extensions - drug effects Cellular biology Enzyme Activation - drug effects HeLa Cells Humans Infections Kinases Lipids Models, Biological Mutation - genetics Phosphatases Phosphates Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Phosphatidylinositol Phosphates - metabolism Phosphatidylinositols Protein Kinase Inhibitors - pharmacology rab5 GTP-Binding Proteins - metabolism Ruffles Salmonella Salmonella - cytology Salmonella - drug effects Salmonella - enzymology Small interfering RNA Vacuoles Vacuoles - drug effects Vacuoles - enzymology
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