The multisubstrate docking site of the MET receptor is dispensable for MET-mediated RAS signaling and cell scattering

The scatter factor/hepatocyte growth factor regulates scattering and morphogenesis of epithelial cells through activation of the MET tyrosine kinase receptor. In particular, the noncatalytic C-terminal tail of MET contains two autophosphorylation tyrosine residues, which form a multisubstrate-bindin...

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Veröffentlicht in:	Molecular biology of the cell 1999-03, Vol.10 (3), p.551-565
Hauptverfasser:	Tulasne, D, Paumelle, R, Weidner, K M, Vandenbunder, B, Fafeur, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adaptor Proteins, Vesicular Transport Animals Binding Sites Cell Line Cell Movement - physiology Dogs GRB10 Adaptor Protein Hepatocyte Growth Factor - metabolism Hepatocyte Growth Factor - pharmacology Mutation Phosphatidylinositol 3-Kinases - metabolism Phosphoproteins - metabolism Phosphorylation Proteins - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-ets Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism ras Proteins - genetics ras Proteins - metabolism Recombinant Proteins - genetics Recombinant Proteins - metabolism Shc Signaling Adaptor Proteins Signal Transduction Transcription Factor AP-1 - metabolism Transcription Factors - metabolism Transcriptional Activation Transfection Tyrosine - metabolism
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