Thymic stromal lymphopoietin: a new cytokine in asthma
Airway epithelial cells provide mechanical and immune protection against pathogens and allergens. Following activation, these cells produce a wide range of cytokines including thymic stromal lymphopoietin (TSLP). Recently it was established that a high level of TSLP is associated with asthma in mice...
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| Veröffentlicht in: | Current opinion in pharmacology 2008-06, Vol.8 (3), p.249-254 |
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| creator | Rochman, Yrina Leonard, Warren J |
| description | Airway epithelial cells provide mechanical and immune protection against pathogens and allergens. Following activation, these cells produce a wide range of cytokines including thymic stromal lymphopoietin (TSLP). Recently it was established that a high level of TSLP is associated with asthma in mice and in humans. These findings suggest that interfering with the ability of cells to respond to TSLP might prevent the development of airway inflammation. Our review presents current knowledge on mediators that induce TSLP production and on the actions of TSLP on different populations of cells that are related to airway inflammation. TSLP affects dendritic cells, T cells, NKT cells, and mast cells, indicative of the broad role of TSLP in the regulation of inflammatory/allergic processes. |
| doi_str_mv | 10.1016/j.coph.2008.03.002 |
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Following activation, these cells produce a wide range of cytokines including thymic stromal lymphopoietin (TSLP). Recently it was established that a high level of TSLP is associated with asthma in mice and in humans. These findings suggest that interfering with the ability of cells to respond to TSLP might prevent the development of airway inflammation. Our review presents current knowledge on mediators that induce TSLP production and on the actions of TSLP on different populations of cells that are related to airway inflammation. 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TSLP affects dendritic cells, T cells, NKT cells, and mast cells, indicative of the broad role of TSLP in the regulation of inflammatory/allergic processes.</description><subject>Animals</subject><subject>Asthma - drug therapy</subject><subject>Asthma - etiology</subject><subject>Cytokines - physiology</subject><subject>Dendritic Cells - physiology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Lymphocytes - physiology</subject><subject>Mast Cells - physiology</subject><subject>Medical Education</subject><subject>Receptors, Cytokine - physiology</subject><subject>Signal Transduction</subject><issn>1471-4892</issn><issn>1471-4973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks1u1DAURiMEoqXwAixQVuwm3GvHjoNQpaqCFqkSC8ra8jg3xNPEDnamKG9Pohl-F8DKlny-T7bPzbLnCAUCyle7woaxKxiAKoAXAOxBdoplhZuyrvjD73tVs5PsSUo7ABScV4-zE1SlAIFwmsnbbh6czdMUw2D6vJ-HsQtjcDQ5_zo3uaevuZ2ncOc85c7nJk3dYJ5mj1rTJ3p2XM-yT-_e3l5eb24-XL2_vLjZWMnltJEttltuyrIkyyppbFM20sitaKUUDamaY2MY1aIVTCESw4aMKK2wouJ2q_hZdn7oHffbgRpLfoqm12N0g4mzDsbp30-86_TncK-ZQAUSl4KXx4IYvuwpTXpwyVLfG09hn3SFUrAS-T9BBkrVwKr_AkFV9QKyA2hjSClS--PaCHoVqHd6FahXgRq4XgQuoRe_Pvhn5GhsAd4cAFq-_d5R1Mk68pYaF8lOugnu7_3nf8Rt77yzpr-jmdIu7KNfhGrUiWnQH9cRWicIFABwJvg3F-TByQ</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>Rochman, Yrina</creator><creator>Leonard, Warren J</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080601</creationdate><title>Thymic stromal lymphopoietin: a new cytokine in asthma</title><author>Rochman, Yrina ; Leonard, Warren J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c636t-6f1fb3a444ec276acd4d6a6b5f665de8931da2e95f52811e21dea54c5c573cb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Asthma - drug therapy</topic><topic>Asthma - etiology</topic><topic>Cytokines - physiology</topic><topic>Dendritic Cells - physiology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Lymphocytes - physiology</topic><topic>Mast Cells - physiology</topic><topic>Medical Education</topic><topic>Receptors, Cytokine - physiology</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rochman, Yrina</creatorcontrib><creatorcontrib>Leonard, Warren J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current opinion in pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rochman, Yrina</au><au>Leonard, Warren J</au><au>Rogers, D</au><au>Donnelly, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thymic stromal lymphopoietin: a new cytokine in asthma</atitle><jtitle>Current opinion in pharmacology</jtitle><addtitle>Curr Opin Pharmacol</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>8</volume><issue>3</issue><spage>249</spage><epage>254</epage><pages>249-254</pages><issn>1471-4892</issn><eissn>1471-4973</eissn><abstract>Airway epithelial cells provide mechanical and immune protection against pathogens and allergens. 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| identifier | ISSN: 1471-4892 |
| ispartof | Current opinion in pharmacology, 2008-06, Vol.8 (3), p.249-254 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Asthma - drug therapy Asthma - etiology Cytokines - physiology Dendritic Cells - physiology Humans Internal Medicine Lymphocytes - physiology Mast Cells - physiology Medical Education Receptors, Cytokine - physiology Signal Transduction |
| title | Thymic stromal lymphopoietin: a new cytokine in asthma |
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