Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma
Summary Head and neck squamous cell carcinoma (HNSCC) involves the upper aerodigestive tract and can destroy the structure and function of organs involved in voice, speech, taste, smell and hearing, as well as vital structures necessary for survival. HNSCC has long been a treatment challenge because...
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| Veröffentlicht in: | International journal of experimental pathology 2005-12, Vol.86 (6), p.347-363 |
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| creator | Thomas, Giovana R. Nadiminti, Hari Regalado, Jacinto |
| description | Summary
Head and neck squamous cell carcinoma (HNSCC) involves the upper aerodigestive tract and can destroy the structure and function of organs involved in voice, speech, taste, smell and hearing, as well as vital structures necessary for survival. HNSCC has long been a treatment challenge because of the high rate of recurrences and of advanced disease at the time of diagnosis. Molecular identification of tissue biomarkers in diagnostic biopsy specimens may not only identify patients at risk for developing HNSCC but may also select patients that may benefit from more aggressive treatment modalities. Several biomarkers studied to date such as the proteins p53, cyclin D1, p16, Cox‐2 enzyme, epidermal growth factor and vascular endothelial growth factor receptors, matrix metalloproteinases and the Fhit marker for genomic instability could be manipulated for the therapeutic benefit of these patients. This review presents the most updated information on molecular biomarkers with the greatest prognostic potential in HNSCC and discusses some factors that contribute to the controversy concerning their prognostic importance. |
| doi_str_mv | 10.1111/j.0959-9673.2005.00447.x |
| format | Article |
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Head and neck squamous cell carcinoma (HNSCC) involves the upper aerodigestive tract and can destroy the structure and function of organs involved in voice, speech, taste, smell and hearing, as well as vital structures necessary for survival. HNSCC has long been a treatment challenge because of the high rate of recurrences and of advanced disease at the time of diagnosis. Molecular identification of tissue biomarkers in diagnostic biopsy specimens may not only identify patients at risk for developing HNSCC but may also select patients that may benefit from more aggressive treatment modalities. Several biomarkers studied to date such as the proteins p53, cyclin D1, p16, Cox‐2 enzyme, epidermal growth factor and vascular endothelial growth factor receptors, matrix metalloproteinases and the Fhit marker for genomic instability could be manipulated for the therapeutic benefit of these patients. This review presents the most updated information on molecular biomarkers with the greatest prognostic potential in HNSCC and discusses some factors that contribute to the controversy concerning their prognostic importance.</description><identifier>ISSN: 0959-9673</identifier><identifier>EISSN: 1365-2613</identifier><identifier>DOI: 10.1111/j.0959-9673.2005.00447.x</identifier><identifier>PMID: 16309541</identifier><language>eng</language><publisher>Oxford, UK; Malden, USA: Blackwell Publishing Ltd/Inc</publisher><subject>Biological and medical sciences ; biomarkers ; Biomarkers, Tumor - genetics ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - pathology ; Current Status Review ; gene expression profiles ; Gene Expression Profiling ; Genes, Tumor Suppressor ; Head and Neck Neoplasms - genetics ; Head and Neck Neoplasms - pathology ; head and neck squamous cell carcinoma ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Neoplasm Recurrence, Local - genetics ; Oligonucleotide Array Sequence Analysis ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Prognosis ; proteomics ; survival ; Tumors</subject><ispartof>International journal of experimental pathology, 2005-12, Vol.86 (6), p.347-363</ispartof><rights>2006 INIST-CNRS</rights><rights>2005 Blackwell Publishing Ltd 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5397-abb3371f700396cfe059cc27d35ad8632cb8b2b83280c77277fb18c5dda0b6f73</citedby><cites>FETCH-LOGICAL-c5397-abb3371f700396cfe059cc27d35ad8632cb8b2b83280c77277fb18c5dda0b6f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517451/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517451/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,27924,27925,45574,45575,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17315469$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16309541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thomas, Giovana R.</creatorcontrib><creatorcontrib>Nadiminti, Hari</creatorcontrib><creatorcontrib>Regalado, Jacinto</creatorcontrib><title>Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma</title><title>International journal of experimental pathology</title><addtitle>Int J Exp Pathol</addtitle><description>Summary
Head and neck squamous cell carcinoma (HNSCC) involves the upper aerodigestive tract and can destroy the structure and function of organs involved in voice, speech, taste, smell and hearing, as well as vital structures necessary for survival. HNSCC has long been a treatment challenge because of the high rate of recurrences and of advanced disease at the time of diagnosis. Molecular identification of tissue biomarkers in diagnostic biopsy specimens may not only identify patients at risk for developing HNSCC but may also select patients that may benefit from more aggressive treatment modalities. Several biomarkers studied to date such as the proteins p53, cyclin D1, p16, Cox‐2 enzyme, epidermal growth factor and vascular endothelial growth factor receptors, matrix metalloproteinases and the Fhit marker for genomic instability could be manipulated for the therapeutic benefit of these patients. This review presents the most updated information on molecular biomarkers with the greatest prognostic potential in HNSCC and discusses some factors that contribute to the controversy concerning their prognostic importance.</description><subject>Biological and medical sciences</subject><subject>biomarkers</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Current Status Review</subject><subject>gene expression profiles</subject><subject>Gene Expression Profiling</subject><subject>Genes, Tumor Suppressor</subject><subject>Head and Neck Neoplasms - genetics</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>head and neck squamous cell carcinoma</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Neoplasm Recurrence, Local - genetics</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Otorhinolaryngology (head neck, general aspects and miscellaneous)</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Prognosis</subject><subject>proteomics</subject><subject>survival</subject><subject>Tumors</subject><issn>0959-9673</issn><issn>1365-2613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFv1DAQhS1ERZeWv4B8gVuCHcd2LCEkuiptpRY4tOI4chyH9TaJt3ZCt_8eh11t4YYvtjTfG7-ZhxCmJKfpfFjnRHGVKSFZXhDCc0LKUubbF2hBmeBZISh7iRYH6Bi9jnFNCGUFla_QMRUs1Uq6QHDjO2umTge8CbZxZvQhYt9i07nBGd1hP43G9xa7AW_06OwwRvzoxhVeWd1gPTR4sOYex4dJ936K2Niuw0YH4wbf61N01Oou2jf7-wTdfTm_XV5m198urpafrzPDmZKZrmvGJG0lIUwJ01rClTGFbBjXTSVYYeqqLuqKFRUxUhZStjWtDG8aTWrRSnaCPu36bqa6t41JNoPuYBNcr8MTeO3g38rgVvDT_4KCU1lymhq83zcI_mGycYTexXkWPdg0FoiqYlKpMoHVDjTBxxhse_iEEpjTgTXMi4d58TCnA3_SgW2Svv3b5LNwH0cC3u0BHdPu26AH4-IzJxnlpVCJ-7jjHl1nn_7bAFydf0-PJM92chdHuz3IdbiHJJEcfny9gMulpLdCUThjvwEw0rwU</recordid><startdate>200512</startdate><enddate>200512</enddate><creator>Thomas, Giovana R.</creator><creator>Nadiminti, Hari</creator><creator>Regalado, Jacinto</creator><general>Blackwell Publishing Ltd/Inc</general><general>Blackwell Science</general><general>Blackwell Science Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200512</creationdate><title>Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma</title><author>Thomas, Giovana R. ; Nadiminti, Hari ; Regalado, Jacinto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5397-abb3371f700396cfe059cc27d35ad8632cb8b2b83280c77277fb18c5dda0b6f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>biomarkers</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Current Status Review</topic><topic>gene expression profiles</topic><topic>Gene Expression Profiling</topic><topic>Genes, Tumor Suppressor</topic><topic>Head and Neck Neoplasms - genetics</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>head and neck squamous cell carcinoma</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Neoplasm Recurrence, Local - genetics</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Otorhinolaryngology (head neck, general aspects and miscellaneous)</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Prognosis</topic><topic>proteomics</topic><topic>survival</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thomas, Giovana R.</creatorcontrib><creatorcontrib>Nadiminti, Hari</creatorcontrib><creatorcontrib>Regalado, Jacinto</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of experimental pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thomas, Giovana R.</au><au>Nadiminti, Hari</au><au>Regalado, Jacinto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma</atitle><jtitle>International journal of experimental pathology</jtitle><addtitle>Int J Exp Pathol</addtitle><date>2005-12</date><risdate>2005</risdate><volume>86</volume><issue>6</issue><spage>347</spage><epage>363</epage><pages>347-363</pages><issn>0959-9673</issn><eissn>1365-2613</eissn><abstract>Summary
Head and neck squamous cell carcinoma (HNSCC) involves the upper aerodigestive tract and can destroy the structure and function of organs involved in voice, speech, taste, smell and hearing, as well as vital structures necessary for survival. HNSCC has long been a treatment challenge because of the high rate of recurrences and of advanced disease at the time of diagnosis. Molecular identification of tissue biomarkers in diagnostic biopsy specimens may not only identify patients at risk for developing HNSCC but may also select patients that may benefit from more aggressive treatment modalities. Several biomarkers studied to date such as the proteins p53, cyclin D1, p16, Cox‐2 enzyme, epidermal growth factor and vascular endothelial growth factor receptors, matrix metalloproteinases and the Fhit marker for genomic instability could be manipulated for the therapeutic benefit of these patients. This review presents the most updated information on molecular biomarkers with the greatest prognostic potential in HNSCC and discusses some factors that contribute to the controversy concerning their prognostic importance.</abstract><cop>Oxford, UK; Malden, USA</cop><pub>Blackwell Publishing Ltd/Inc</pub><pmid>16309541</pmid><doi>10.1111/j.0959-9673.2005.00447.x</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences biomarkers Biomarkers, Tumor - genetics Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Current Status Review gene expression profiles Gene Expression Profiling Genes, Tumor Suppressor Head and Neck Neoplasms - genetics Head and Neck Neoplasms - pathology head and neck squamous cell carcinoma Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Neoplasm Recurrence, Local - genetics Oligonucleotide Array Sequence Analysis Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prognosis proteomics survival Tumors |
| title | Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma |
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