Synaptic inhibition by glycine acting at a metabotropic receptor in tiger salamander retina
Glycine is the lone fast neurotransmitter for which a metabotropic pathway has not been identified. In retina, we found a strychnine-insensitive glycine response in bipolar and ganglion cells. This glycine response reduced high voltage-activated calcium current. It was G-protein mediated and protein...
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| Veröffentlicht in: | The Journal of physiology 2008-06, Vol.586 (12), p.2913-2926 |
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| container_title | The Journal of physiology |
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| creator | Hou, Mingli Duan, Lei Slaughter, Malcolm M. |
| description | Glycine is the lone fast neurotransmitter for which a metabotropic pathway has not been identified. In retina, we found a
strychnine-insensitive glycine response in bipolar and ganglion cells. This glycine response reduced high voltage-activated
calcium current. It was G-protein mediated and protein kinase A dependent. The EC 50 of the metabotropic glycine response is 3 μ m , an order of magnitude lower than the ionotropic glycine receptor in the same retina. The bipolar cell glutamatergic input
to ganglion cells was suppressed by metabotropic glycine action. The synaptic output of about two-thirds of bipolar cells
and calcium current in two-thirds of ganglion cells are sensitive to the action of glycine at metabotropic receptors, suggesting
this signal regulates specific synaptic pathways in proximal retina. This study resolves the curious absence of a metabotropic
glycine pathway in the nervous system and reveals that the major fast inhibitory neurotransmitters, GABA and glycine, both
activate G-protein-coupled pathways as well. |
| doi_str_mv | 10.1113/jphysiol.2008.153437 |
| format | Article |
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strychnine-insensitive glycine response in bipolar and ganglion cells. This glycine response reduced high voltage-activated
calcium current. It was G-protein mediated and protein kinase A dependent. The EC 50 of the metabotropic glycine response is 3 μ m , an order of magnitude lower than the ionotropic glycine receptor in the same retina. The bipolar cell glutamatergic input
to ganglion cells was suppressed by metabotropic glycine action. The synaptic output of about two-thirds of bipolar cells
and calcium current in two-thirds of ganglion cells are sensitive to the action of glycine at metabotropic receptors, suggesting
this signal regulates specific synaptic pathways in proximal retina. This study resolves the curious absence of a metabotropic
glycine pathway in the nervous system and reveals that the major fast inhibitory neurotransmitters, GABA and glycine, both
activate G-protein-coupled pathways as well.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.2008.153437</identifier><identifier>PMID: 18440992</identifier><language>eng</language><publisher>Oxford, UK: The Physiological Society</publisher><subject>Ambystoma tigrinum ; Animals ; Cells, Cultured ; Glycine - metabolism ; Neural Inhibition - physiology ; Neuroscience ; Receptors, Glycine - metabolism ; Retina - cytology ; Retina - physiology ; Retinal Ganglion Cells - physiology ; Synaptic Transmission - physiology ; Urodela - physiology</subject><ispartof>The Journal of physiology, 2008-06, Vol.586 (12), p.2913-2926</ispartof><rights>2008 The Authors. Journal compilation © 2008 The Physiological Society</rights><rights>2008 The Authors. Journal compilation © 2008 The Physiological Society 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5219-411ba719c082d07f41538f4978c43353f8e34b2e6fa7b1db906f761e62bc8d733</citedby><cites>FETCH-LOGICAL-c5219-411ba719c082d07f41538f4978c43353f8e34b2e6fa7b1db906f761e62bc8d733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517204/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517204/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18440992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hou, Mingli</creatorcontrib><creatorcontrib>Duan, Lei</creatorcontrib><creatorcontrib>Slaughter, Malcolm M.</creatorcontrib><title>Synaptic inhibition by glycine acting at a metabotropic receptor in tiger salamander retina</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>Glycine is the lone fast neurotransmitter for which a metabotropic pathway has not been identified. In retina, we found a
strychnine-insensitive glycine response in bipolar and ganglion cells. This glycine response reduced high voltage-activated
calcium current. It was G-protein mediated and protein kinase A dependent. The EC 50 of the metabotropic glycine response is 3 μ m , an order of magnitude lower than the ionotropic glycine receptor in the same retina. The bipolar cell glutamatergic input
to ganglion cells was suppressed by metabotropic glycine action. The synaptic output of about two-thirds of bipolar cells
and calcium current in two-thirds of ganglion cells are sensitive to the action of glycine at metabotropic receptors, suggesting
this signal regulates specific synaptic pathways in proximal retina. This study resolves the curious absence of a metabotropic
glycine pathway in the nervous system and reveals that the major fast inhibitory neurotransmitters, GABA and glycine, both
activate G-protein-coupled pathways as well.</description><subject>Ambystoma tigrinum</subject><subject>Animals</subject><subject>Cells, Cultured</subject><subject>Glycine - metabolism</subject><subject>Neural Inhibition - physiology</subject><subject>Neuroscience</subject><subject>Receptors, Glycine - metabolism</subject><subject>Retina - cytology</subject><subject>Retina - physiology</subject><subject>Retinal Ganglion Cells - physiology</subject><subject>Synaptic Transmission - physiology</subject><subject>Urodela - physiology</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU2L1TAUhoMozp2r_0CkK8FFrzlJ2iQbQYbxiwEFx5WLkKZpm6FtapI7Q_-9GXr9WukqB_K8L-fwIPQM8AEA6KubZVij8-OBYCwOUFFG-QO0A1bLknNJH6IdxoSUlFdwhs5jvMEYKJbyMToDwVieyA59-7LOeknOFG4eXOOS83PRrEU_rsbNttAmubkvdCp0MdmkG5-CXzIerLFL8iHniuR6G4qoRz3puc1jsDmln6BHnR6jfXp69-jr28vri_fl1ad3Hy7eXJWmIiBLBtBoDtJgQVrMO5ZvER2TXBhGaUU7YSlriK07zRtoG4nrjtdga9IY0XJK9-j11rscm8m2xs4p6FEtwU06rMprp_7-md2gen-rSAWcYJYLXpwKgv9-tDGpyUVjx1HP1h-jqiUBDFj8EyRYUswEySDbQBN8jMF2v7YBrO71qZ_61L0-tenLsed_XvI7dPKVAbkBd26063-VquuPn4nMi-3Ryy07uH64c8GqjY7eOJtWVYlaAVFEAqU_AIF4usI</recordid><startdate>20080615</startdate><enddate>20080615</enddate><creator>Hou, Mingli</creator><creator>Duan, Lei</creator><creator>Slaughter, Malcolm M.</creator><general>The Physiological Society</general><general>Blackwell Publishing Ltd</general><general>Blackwell Science Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080615</creationdate><title>Synaptic inhibition by glycine acting at a metabotropic receptor in tiger salamander retina</title><author>Hou, Mingli ; Duan, Lei ; Slaughter, Malcolm M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5219-411ba719c082d07f41538f4978c43353f8e34b2e6fa7b1db906f761e62bc8d733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Ambystoma tigrinum</topic><topic>Animals</topic><topic>Cells, Cultured</topic><topic>Glycine - metabolism</topic><topic>Neural Inhibition - physiology</topic><topic>Neuroscience</topic><topic>Receptors, Glycine - metabolism</topic><topic>Retina - cytology</topic><topic>Retina - physiology</topic><topic>Retinal Ganglion Cells - physiology</topic><topic>Synaptic Transmission - physiology</topic><topic>Urodela - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hou, Mingli</creatorcontrib><creatorcontrib>Duan, Lei</creatorcontrib><creatorcontrib>Slaughter, Malcolm M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hou, Mingli</au><au>Duan, Lei</au><au>Slaughter, Malcolm M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synaptic inhibition by glycine acting at a metabotropic receptor in tiger salamander retina</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>2008-06-15</date><risdate>2008</risdate><volume>586</volume><issue>12</issue><spage>2913</spage><epage>2926</epage><pages>2913-2926</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><abstract>Glycine is the lone fast neurotransmitter for which a metabotropic pathway has not been identified. In retina, we found a
strychnine-insensitive glycine response in bipolar and ganglion cells. This glycine response reduced high voltage-activated
calcium current. It was G-protein mediated and protein kinase A dependent. The EC 50 of the metabotropic glycine response is 3 μ m , an order of magnitude lower than the ionotropic glycine receptor in the same retina. The bipolar cell glutamatergic input
to ganglion cells was suppressed by metabotropic glycine action. The synaptic output of about two-thirds of bipolar cells
and calcium current in two-thirds of ganglion cells are sensitive to the action of glycine at metabotropic receptors, suggesting
this signal regulates specific synaptic pathways in proximal retina. This study resolves the curious absence of a metabotropic
glycine pathway in the nervous system and reveals that the major fast inhibitory neurotransmitters, GABA and glycine, both
activate G-protein-coupled pathways as well.</abstract><cop>Oxford, UK</cop><pub>The Physiological Society</pub><pmid>18440992</pmid><doi>10.1113/jphysiol.2008.153437</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); PubMed Central |
| subjects | Ambystoma tigrinum Animals Cells, Cultured Glycine - metabolism Neural Inhibition - physiology Neuroscience Receptors, Glycine - metabolism Retina - cytology Retina - physiology Retinal Ganglion Cells - physiology Synaptic Transmission - physiology Urodela - physiology |
| title | Synaptic inhibition by glycine acting at a metabotropic receptor in tiger salamander retina |
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