Silencing preBötzinger Complex somatostatin-expressing neurons induces persistent apnea in awake rat

Delineating neurons that underlie complex behaviors is of fundamental interest. Using adeno-associated virus 2, we expressed the Drosophila allatostatin receptor in somatostatin (Sst)-expressing neurons in the preBötzinger Complex (preBötC). Rapid silencing of these neurons in awake rats induced a p...

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Veröffentlicht in:	Nature neuroscience 2008-05, Vol.11 (5), p.538-540
Hauptverfasser:	Feldman, Jack L, Tan, Wenbin, Janczewski, Wiktor A, Yang, Paul, Shao, Xuesi M, Callaway, Edward M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Apnea Apnea - chemically induced Apnea - genetics Apnea - physiopathology Behavioral Sciences Biological Clocks - drug effects Biological Clocks - genetics Biological Techniques Biomarkers - metabolism Biomedical and Life Sciences Biomedicine brief-communication Dependovirus - genetics Drosophila Drosophila Proteins - biosynthesis Drosophila Proteins - genetics Genetic aspects Genetic Vectors Green Fluorescent Proteins - genetics Infections Nerve Net - cytology Nerve Net - drug effects Nerve Net - metabolism Neural Inhibition - drug effects Neural Inhibition - genetics Neurobiology Neurodegeneration Neurons Neurons - drug effects Neurons - metabolism Neuropeptides - pharmacology Neurosciences Periodicity Physiological aspects Rats Receptors, G-Protein-Coupled - biosynthesis Receptors, G-Protein-Coupled - genetics Receptors, Neurokinin-1 - metabolism Receptors, Neuropeptide - biosynthesis Receptors, Neuropeptide - genetics Respiratory Center - cytology Respiratory Center - drug effects Respiratory Center - metabolism Respiratory Physiological Phenomena Risk factors Somatostatin Somatostatin - metabolism Spinal cord Transfection - methods Viral infections Wakefulness - physiology
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