Rosiglitazone, a PPAR gamma agonist, attenuates inflammation after surgical brain injury in rodents

Abstract Introduction Surgical brain injury (SBI) is unavoidable during many neurosurgical procedures. This inevitable brain injury can result in post-operative complications including brain edema, blood–brain barrier disruption (BBB) and cell death in susceptible areas. Rosiglitazone (RSG), a PPAR-...

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Veröffentlicht in:	Brain research 2008-06, Vol.1215, p.218-224
Hauptverfasser:	Hyong, Amy, Jadhav, Vikram, Lee, Steve, Tong, Wenni, Rowe, Jamaine, Zhang, John H, Tang, Jiping
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Biological and medical sciences Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Blood–brain barrier Brain edema Brain Edema - etiology Brain Edema - metabolism Brain Edema - prevention & control Brain Injuries - etiology Brain Injuries - metabolism Brain Injuries - prevention & control Disease Models, Animal Drug Administration Schedule Inflammation Inflammation - etiology Inflammation - metabolism Inflammation - prevention & control Injuries of the nervous system and the skull. Diseases due to physical agents Intraoperative Complications Male Medical sciences Myeloperoxidase Neurology Neuroprotective Agents - administration & dosage Neurosurgical Procedures - adverse effects Peroxidase - metabolism Postoperative Complications - prevention & control PPAR gamma - agonists PPAR gamma - metabolism Random Allocation Rats Rats, Sprague-Dawley Rosiglitazone Surgical brain injury Thiazolidinediones - administration & dosage Traumas. Diseases due to physical agents Treatment Outcome
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