Profile of health-related quality of life outcomes after liver transplantation: univariate effects and multivariate models
Aim. To test the effects of pre- and post-transplant clinical covariates on post-transplant health-related quality of life (HRQOL) score profiles in liver transplant recipients. Material and methods. HRQOL was measured before and after transplantation using the SF-36® Health Survey. Clinical data [d...
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| Veröffentlicht in: | HPB (Oxford, England) England), 2008-02, Vol.10 (1), p.30-37 |
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| creator | Russell, R.T. Feurer, I.D. Wisawatapnimit, P. Lillie, E.S. Castaldo, E.T. Wright Pinson, C. |
| description | Aim. To test the effects of pre- and post-transplant clinical covariates on post-transplant health-related quality of life (HRQOL) score profiles in liver transplant recipients. Material and methods. HRQOL was measured before and after transplantation using the SF-36® Health Survey. Clinical data [diagnosis, model of end-stage liver disease (MELD) score, post-transplant rejection and infection episodes], pre-transplant functional performance (FP), and demographics were collected. Multivariate models for the eight SF-36 scales and two summary components were developed using multiple regression. Discriminant analysis was used to test whether the score profiles differentiated among recipients with and without hepatitis C virus (HCV) infection. Results. 104 adults reported pre- and post-transplant HRQOL. Time post-transplant averaged 9±8 months (range 1–39). Scores on all SF-36 measures improved from pre- to post-transplant (p |
| doi_str_mv | 10.1080/13651820701883106 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2504851</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1365182X15300228</els_id><sourcerecordid>733539566</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4499-d7cc1323ec44617a5b07096a3d2aa5ddeea570895d4502ca2b953ecf4b4167753</originalsourceid><addsrcrecordid>eNqFkV-L1DAUxYso7rr6AXyRvvlUTZomaRWEddEdYdEBlfUtZJJbJ5o2s0k6On5679BhVAR9yb_7Oye5OUXxkJInlLTkKWWC07YmktC2ZZSIW8UpbaSsai6b27jGeoXAp5PiXkpfCKkpod3d4oS2ouOSi9PixzKG3nkoQ1-uQfu8riJ4ncGWN5P2Lu_2Fe96JKZswgCp1H2GiGdbHHPUY9p4PWadXRifldPotjo6dCih78Fk5EdbDpPPx8IQLPh0v7jTa5_gwWE-Kz6-fvXhYlFdvbt8c3F-VZmm6brKSmMoqxngVlCp-Qr77YRmttaaWwuguSRtx23DSW10veo4wn2zaqiQkrOz4sXsu5lWA1gDIz7aq010g447FbRTf1ZGt1afw1bVnDQtp2jw-GAQw80EKavBJQMeu4YwJSUZ46zjQiBJZ9LEkFKE_ngLJWofmforMtQ8-v15vxSHjBDgM_ANc9r931Etli8p71BXzTqXMnw_6nT8qoRkkqvrt5fqetEs3-OHqf09z2ces4Gtg6iScTAasC5ijsoG9482fgKqL8Wf</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733539566</pqid></control><display><type>article</type><title>Profile of health-related quality of life outcomes after liver transplantation: univariate effects and multivariate models</title><source>Access via Wiley Online Library</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Russell, R.T. ; Feurer, I.D. ; Wisawatapnimit, P. ; Lillie, E.S. ; Castaldo, E.T. ; Wright Pinson, C.</creator><creatorcontrib>Russell, R.T. ; Feurer, I.D. ; Wisawatapnimit, P. ; Lillie, E.S. ; Castaldo, E.T. ; Wright Pinson, C.</creatorcontrib><description>Aim. To test the effects of pre- and post-transplant clinical covariates on post-transplant health-related quality of life (HRQOL) score profiles in liver transplant recipients. Material and methods. HRQOL was measured before and after transplantation using the SF-36® Health Survey. Clinical data [diagnosis, model of end-stage liver disease (MELD) score, post-transplant rejection and infection episodes], pre-transplant functional performance (FP), and demographics were collected. Multivariate models for the eight SF-36 scales and two summary components were developed using multiple regression. Discriminant analysis was used to test whether the score profiles differentiated among recipients with and without hepatitis C virus (HCV) infection. Results. 104 adults reported pre- and post-transplant HRQOL. Time post-transplant averaged 9±8 months (range 1–39). Scores on all SF-36 measures improved from pre- to post-transplant (p<0.001), and 7 of 10 models were significant (p<0.05). After controlling for pre-transplant HRQOL and time post-transplant, HCV infection had a negative effect on the role physical, bodily pain, and role emotional scales. History of a rejection episode had a negative effect on the bodily pain and vitality scales. MELD scores ≥18 had a positive effect on the role physical scale. Pre-transplant FP and post-transplant infection episodes did not affect post-transplant HRQOL. HCV infection had a significant effect on the SF-36 score profile (canonical correlation=0.50; p<0.001). Conclusions. Pre-transplant HCV infection, MELD score, and post-transplant rejection episodes have significant independent effects on HRQOL after liver transplantation. Their specific effects vary among the individual SF-36 scales, and HRQOL score profiles differ among HCV+ and HCV– recipients.</description><identifier>ISSN: 1365-182X</identifier><identifier>EISSN: 1477-2574</identifier><identifier>DOI: 10.1080/13651820701883106</identifier><identifier>PMID: 18695756</identifier><language>eng</language><publisher>Oxford, UK: Elsevier Ltd</publisher><subject>Graft rejection ; HCV ; liver transplantation ; MELD ; Original ; quality of life ; score profile</subject><ispartof>HPB (Oxford, England), 2008-02, Vol.10 (1), p.30-37</ispartof><rights>2008 International Hepato-Pancreato-Biliary Association</rights><rights>2008 Taylor & Francis</rights><rights>Taylor & Francis, 2008 2008 Taylor & Francis</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4499-d7cc1323ec44617a5b07096a3d2aa5ddeea570895d4502ca2b953ecf4b4167753</citedby><cites>FETCH-LOGICAL-c4499-d7cc1323ec44617a5b07096a3d2aa5ddeea570895d4502ca2b953ecf4b4167753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504851/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504851/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,27924,27925,45574,45575,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18695756$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Russell, R.T.</creatorcontrib><creatorcontrib>Feurer, I.D.</creatorcontrib><creatorcontrib>Wisawatapnimit, P.</creatorcontrib><creatorcontrib>Lillie, E.S.</creatorcontrib><creatorcontrib>Castaldo, E.T.</creatorcontrib><creatorcontrib>Wright Pinson, C.</creatorcontrib><title>Profile of health-related quality of life outcomes after liver transplantation: univariate effects and multivariate models</title><title>HPB (Oxford, England)</title><addtitle>HPB (Oxford)</addtitle><description>Aim. To test the effects of pre- and post-transplant clinical covariates on post-transplant health-related quality of life (HRQOL) score profiles in liver transplant recipients. Material and methods. HRQOL was measured before and after transplantation using the SF-36® Health Survey. Clinical data [diagnosis, model of end-stage liver disease (MELD) score, post-transplant rejection and infection episodes], pre-transplant functional performance (FP), and demographics were collected. Multivariate models for the eight SF-36 scales and two summary components were developed using multiple regression. Discriminant analysis was used to test whether the score profiles differentiated among recipients with and without hepatitis C virus (HCV) infection. Results. 104 adults reported pre- and post-transplant HRQOL. Time post-transplant averaged 9±8 months (range 1–39). Scores on all SF-36 measures improved from pre- to post-transplant (p<0.001), and 7 of 10 models were significant (p<0.05). After controlling for pre-transplant HRQOL and time post-transplant, HCV infection had a negative effect on the role physical, bodily pain, and role emotional scales. History of a rejection episode had a negative effect on the bodily pain and vitality scales. MELD scores ≥18 had a positive effect on the role physical scale. Pre-transplant FP and post-transplant infection episodes did not affect post-transplant HRQOL. HCV infection had a significant effect on the SF-36 score profile (canonical correlation=0.50; p<0.001). Conclusions. Pre-transplant HCV infection, MELD score, and post-transplant rejection episodes have significant independent effects on HRQOL after liver transplantation. Their specific effects vary among the individual SF-36 scales, and HRQOL score profiles differ among HCV+ and HCV– recipients.</description><subject>Graft rejection</subject><subject>HCV</subject><subject>liver transplantation</subject><subject>MELD</subject><subject>Original</subject><subject>quality of life</subject><subject>score profile</subject><issn>1365-182X</issn><issn>1477-2574</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFkV-L1DAUxYso7rr6AXyRvvlUTZomaRWEddEdYdEBlfUtZJJbJ5o2s0k6On5679BhVAR9yb_7Oye5OUXxkJInlLTkKWWC07YmktC2ZZSIW8UpbaSsai6b27jGeoXAp5PiXkpfCKkpod3d4oS2ouOSi9PixzKG3nkoQ1-uQfu8riJ4ncGWN5P2Lu_2Fe96JKZswgCp1H2GiGdbHHPUY9p4PWadXRifldPotjo6dCih78Fk5EdbDpPPx8IQLPh0v7jTa5_gwWE-Kz6-fvXhYlFdvbt8c3F-VZmm6brKSmMoqxngVlCp-Qr77YRmttaaWwuguSRtx23DSW10veo4wn2zaqiQkrOz4sXsu5lWA1gDIz7aq010g447FbRTf1ZGt1afw1bVnDQtp2jw-GAQw80EKavBJQMeu4YwJSUZ46zjQiBJZ9LEkFKE_ngLJWofmforMtQ8-v15vxSHjBDgM_ANc9r931Etli8p71BXzTqXMnw_6nT8qoRkkqvrt5fqetEs3-OHqf09z2ces4Gtg6iScTAasC5ijsoG9482fgKqL8Wf</recordid><startdate>200802</startdate><enddate>200802</enddate><creator>Russell, R.T.</creator><creator>Feurer, I.D.</creator><creator>Wisawatapnimit, P.</creator><creator>Lillie, E.S.</creator><creator>Castaldo, E.T.</creator><creator>Wright Pinson, C.</creator><general>Elsevier Ltd</general><general>Blackwell Publishing Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>BSCLL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200802</creationdate><title>Profile of health-related quality of life outcomes after liver transplantation: univariate effects and multivariate models</title><author>Russell, R.T. ; Feurer, I.D. ; Wisawatapnimit, P. ; Lillie, E.S. ; Castaldo, E.T. ; Wright Pinson, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4499-d7cc1323ec44617a5b07096a3d2aa5ddeea570895d4502ca2b953ecf4b4167753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Graft rejection</topic><topic>HCV</topic><topic>liver transplantation</topic><topic>MELD</topic><topic>Original</topic><topic>quality of life</topic><topic>score profile</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Russell, R.T.</creatorcontrib><creatorcontrib>Feurer, I.D.</creatorcontrib><creatorcontrib>Wisawatapnimit, P.</creatorcontrib><creatorcontrib>Lillie, E.S.</creatorcontrib><creatorcontrib>Castaldo, E.T.</creatorcontrib><creatorcontrib>Wright Pinson, C.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>HPB (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Russell, R.T.</au><au>Feurer, I.D.</au><au>Wisawatapnimit, P.</au><au>Lillie, E.S.</au><au>Castaldo, E.T.</au><au>Wright Pinson, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Profile of health-related quality of life outcomes after liver transplantation: univariate effects and multivariate models</atitle><jtitle>HPB (Oxford, England)</jtitle><addtitle>HPB (Oxford)</addtitle><date>2008-02</date><risdate>2008</risdate><volume>10</volume><issue>1</issue><spage>30</spage><epage>37</epage><pages>30-37</pages><issn>1365-182X</issn><eissn>1477-2574</eissn><abstract>Aim. To test the effects of pre- and post-transplant clinical covariates on post-transplant health-related quality of life (HRQOL) score profiles in liver transplant recipients. Material and methods. HRQOL was measured before and after transplantation using the SF-36® Health Survey. Clinical data [diagnosis, model of end-stage liver disease (MELD) score, post-transplant rejection and infection episodes], pre-transplant functional performance (FP), and demographics were collected. Multivariate models for the eight SF-36 scales and two summary components were developed using multiple regression. Discriminant analysis was used to test whether the score profiles differentiated among recipients with and without hepatitis C virus (HCV) infection. Results. 104 adults reported pre- and post-transplant HRQOL. Time post-transplant averaged 9±8 months (range 1–39). Scores on all SF-36 measures improved from pre- to post-transplant (p<0.001), and 7 of 10 models were significant (p<0.05). After controlling for pre-transplant HRQOL and time post-transplant, HCV infection had a negative effect on the role physical, bodily pain, and role emotional scales. History of a rejection episode had a negative effect on the bodily pain and vitality scales. MELD scores ≥18 had a positive effect on the role physical scale. Pre-transplant FP and post-transplant infection episodes did not affect post-transplant HRQOL. HCV infection had a significant effect on the SF-36 score profile (canonical correlation=0.50; p<0.001). Conclusions. Pre-transplant HCV infection, MELD score, and post-transplant rejection episodes have significant independent effects on HRQOL after liver transplantation. Their specific effects vary among the individual SF-36 scales, and HRQOL score profiles differ among HCV+ and HCV– recipients.</abstract><cop>Oxford, UK</cop><pub>Elsevier Ltd</pub><pmid>18695756</pmid><doi>10.1080/13651820701883106</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Graft rejection HCV liver transplantation MELD Original quality of life score profile |
| title | Profile of health-related quality of life outcomes after liver transplantation: univariate effects and multivariate models |
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