A Cyclin D1/microRNA 17/20 Regulatory Feedback Loop in Control of Breast Cancer Cell Proliferation

Decreased expression of specific microRNAs (miRNAs) occurs in human tumors, which suggests a function for miRNAs in tumor suppression. Herein, levels of the miR-17-5p/miR-20a miRNA cluster were inversely correlated to cyclin D1 abundance in human breast tumors and cell lines. MiR-17/20 suppressed br...

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Veröffentlicht in:	The Journal of cell biology 2008-08, Vol.182 (3), p.509-517
Hauptverfasser:	Yu, Zuoren, Wang, Chenguang, Wang, Min, Li, Zhiping, Casimiro, Mathew C., Liu, Manran, Wu, Kongming, Whittle, James, Ju, Xiaoming, Hyslop, Terry, McCue, Peter, Pestell, Richard G.
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Animals Base Sequence Binding Sites Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cell cycle Cell growth Cell Line, Tumor Cell lines Cell Proliferation Cells Conserved Sequence Cyclin D1 - genetics Cyclins Down-Regulation Epithelial cells Feedback, Physiological G1 Phase Gene Expression Regulation, Neoplastic Humans Mice Mice, Inbred C57BL MicroRNA MicroRNAs - genetics Molecular Sequence Data Promoter Regions, Genetic - genetics Tumor cell line Tumors
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