T cells and in situ cryoglobulin deposition in the pathogenesis of lupus nephritis

Abstract We discuss a 53-year-old woman with systemic lupus erythematosus who presented with vasculitis, hypocomplementemia and nephritis. Although her serum complement 4 (C4) levels were zero, she had four copies of C4 gene. Renal biopsy revealed membranoproliferative glomerulonephritis and the pre...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2008-07, Vol.128 (1), p.1-7
Hauptverfasser:	Cohen, Robert A, Bayliss, George, Crispin, Jose C, Kane-Wanger, Gwen F, Van Beek, Christine A, Kyttaris, Vasileios C, Avalos, Ingrid, Yu, C. Yung, Tsokos, George C, Stillman, Isaac E
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Anti-Inflammatory Agents - therapeutic use Biological and medical sciences Complement Complement C4 - deficiency Cryoglobulins Cryoglobulins - metabolism Dermatology Female Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Hyaluronan Receptors - metabolism Kidneys Lupus Lupus Nephritis - immunology Lupus Nephritis - pathology Lupus Nephritis - physiopathology Medical sciences Microscopy, Electron, Transmission Middle Aged Mycophenolic Acid - analogs & derivatives Mycophenolic Acid - therapeutic use Nephrology. Urinary tract diseases Prednisone - therapeutic use Skin involvement in other diseases. Miscellaneous. General aspects T cells T-Lymphocytes - immunology T-Lymphocytes - metabolism Urinary system involvement in other diseases. Miscellaneous
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