Subepicardial phase 0 block and discontinuous transmural conduction underlie right precordial ST-segment elevation by a SCN5A loss-of-function mutation

Departments of 1 Cardiology, 2 Molecular Cell Biology and Genetics, 3 Clinical Genetics, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht and Maastricht University, Maastricht, The Netherlands; and 4 Cardiac Bioelectricity and Arrhythmia Center, Washington University in St....

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2008-07, Vol.295 (1), p.H48-H58
Hauptverfasser:	Bebarova, Marketa, O'Hara, Tom, Geelen, Jan L. M. C, Jongbloed, Roselie J, Timmermans, Carl, Arens, Yvonne H, Rodriguez, Luz-Maria, Rudy, Yoram, Volders, Paul G. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Adult Animals Brugada Syndrome - genetics Brugada Syndrome - metabolism Brugada Syndrome - physiopathology Calcium - metabolism Calcium Channels, L-Type - metabolism Cardiology CHO Cells Computer Simulation Cricetinae Cricetulus Electrocardiography Genetic Predisposition to Disease Heart Heart Ventricles - metabolism Humans Male Medical disorders Models, Cardiovascular Muscle Proteins - genetics Muscle Proteins - metabolism Mutagenesis, Site-Directed Mutation Mutation, Missense Myocardium - metabolism NAV1.5 Voltage-Gated Sodium Channel Patch-Clamp Techniques Pericardium - metabolism Pericardium - physiopathology Sodium Sodium - metabolism Sodium Channels - genetics Sodium Channels - metabolism Time Factors Transfection
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