Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize β-catenin independently of Frizzled proteins

Secreted signaling proteins of the Wnt family are known to regulate a diverse range of developmental processes, and their signaling pathway through β -catenin is frequently activated in cancer. The identification of both Frizzled and LRP5/6 (LRP: low-density lipoprotein receptor-related protein) pro...

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Veröffentlicht in:	Oncogene 2004-06, Vol.23 (28), p.4873-4884
Hauptverfasser:	Brennan, Keith, Gonzalez-Sancho, José M, Castelo-Soccio, Leslie A, Howe, Louise R, Brown, Anthony MC
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Base Sequence beta Catenin Biological and medical sciences Cell Biology Cell Line Cell physiology Cell receptors Cell structures and functions Cell surface Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cytoskeletal Proteins - physiology DNA Primers Drosophila melanogaster Frizzled protein Frizzled Receptors Fundamental and applied biological sciences. Psychology Genes, Reporter Human Genetics Humans Internal Medicine Intracellular signalling LDL-Receptor Related Proteins Ligands Low Density Lipoprotein Receptor-Related Protein-5 Low Density Lipoprotein Receptor-Related Protein-6 LRP5 protein Luciferases - analysis Medicine Medicine & Public Health Miscellaneous Molecular and cellular biology Oncogenes Oncology original-paper Proteins Proteins - physiology Receptor density Receptors, LDL - genetics Receptors, LDL - physiology Reverse Transcriptase Polymerase Chain Reaction Sequence Deletion Signal transduction Signal Transduction - physiology Structure-function relationships Trans-Activators - physiology Transfection Wnt protein β-Catenin
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