Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain

Burning of Boswellia resin as incense has been part of religious and cultural ceremonies for millennia and is believed to contribute to the spiritual exaltation associated with such events. Transient receptor potential vanilloid (TRPV) 3 is an ion channel implicated in the perception of warmth in th...

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Veröffentlicht in:	The FASEB journal 2008-08, Vol.22 (8), p.3024-3034
Hauptverfasser:	Moussaieff, Arieh, Rimmerman, Neta, Bregman, Tatiana, Straiker, Alex, Felder, Christian C, Shoham, Shai, Kashman, Yoel, Huang, Susan M, Lee, Hyosang, Shohami, Esther, Mackie, Ken, Caterina, Michael J, Walker, J. Michael, Fride, Ester, Mechoulam, Raphael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents - isolation & purification Anti-Anxiety Agents - pharmacology Antidepressive Agents - isolation & purification Antidepressive Agents - pharmacology anxiety Behavior, Animal - drug effects Boswellia Boswellia - chemistry Brain - drug effects Brain - metabolism Cell Line depression Diterpenes - isolation & purification Diterpenes - pharmacology Female frankincense Humans Mice Mice, Inbred C57BL Mice, Knockout Plants, Medicinal - chemistry Proto-Oncogene Proteins c-fos - metabolism Psychotropic Drugs - isolation & purification Psychotropic Drugs - pharmacology Recombinant Proteins - genetics Recombinant Proteins - metabolism Research Communications TRPV Cation Channels - agonists TRPV Cation Channels - deficiency TRPV Cation Channels - genetics TRPV Cation Channels - metabolism
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