Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics

Abstract Following CD4 receptor binding to the HIV-1 envelope spike (Env), the conserved N-heptad repeat (NHR) region of gp41 forms a coiled-coil that is a precursor to the fusion reaction. Although it has been a target of drug and vaccine design, there are few monoclonal antibody (mAb) tools with w...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2008-07, Vol.377 (1), p.170-183
Hauptverfasser:	Nelson, Josh D, Kinkead, Heather, Brunel, Florence M, Leaman, Dan, Jensen, Richard, Louis, John M, Maruyama, Toshiaki, Bewley, Carole A, Bowdish, Katherine, Clore, G. Marius, Dawson, Philip E, Frederickson, Shana, Mage, Rose G, Richman, Douglas D, Burton, Dennis R, Zwick, Michael B
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES AIDS VIRUS Amino Acid Sequence Amino Acid Substitution Animals Antibodies, Monoclonal - genetics Antibody neutralization BACTERIOPHAGES Binding Sites Cardiolipins - immunology Cross Reactions DRUGS Epitope exposure Epitopes - chemistry Epitopes - genetics Fusion intermediate HIV Antibodies - genetics HIV Envelope Protein gp41 - chemistry HIV Envelope Protein gp41 - genetics HIV Envelope Protein gp41 - immunology HIV-1 - genetics HIV-1 - immunology HIV-1 gp41 Human immunodeficiency virus 1 Humans In Vitro Techniques Infectious Disease Molecular Mimicry Molecular Sequence Data MONOCLONAL ANTIBODIES Neutralization Tests PEPTIDES Phage display Protein Structure, Tertiary RABBITS RECEPTORS Repetitive Sequences, Amino Acid Sequence Homology, Amino Acid Six-helix bundle Vaccine design VACCINES Virus capture
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!