Protein Targets of Reactive Metabolites of Thiobenzamide in Rat Liver in Vivo

Thiobenzamide (TB) is a potent hepatotoxin in rats, causing dose-dependent hyperbilirubinemia, steatosis, and centrolobular necrosis. These effects arise subsequent to and appear to result from the covalent binding of the iminosulfinic acid metabolite of TB to cellular proteins and phosphatidylethan...

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Veröffentlicht in:	Chemical research in toxicology 2008-07, Vol.21 (7), p.1432-1442
Hauptverfasser:	Ikehata, Keisuke, Duzhak, Tatyana G, Galeva, Nadezhda A, Ji, Tao, Koen, Yakov M, Hanzlik, Robert P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antitubercular Agents - chemistry Antitubercular Agents - pharmacokinetics Antitubercular Agents - toxicity Cell Fractionation Cytosol - chemistry Cytosol - metabolism Disease Models, Animal Electrophoresis, Gel, Two-Dimensional Injections, Intraperitoneal Liver - chemistry Liver - drug effects Liver - metabolism Male Microsomes, Liver - chemistry Microsomes, Liver - drug effects Microsomes, Liver - metabolism Peptide Mapping Protein Binding Proteins - chemistry Proteins - drug effects Proteins - metabolism Proteomics Rats Rats, Sprague-Dawley Thioamides - chemistry Thioamides - pharmacokinetics Thioamides - toxicity
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