Tissue transglutaminase modulates α‐synuclein oligomerization

We have studied the interaction of the enzyme tissue transglutaminase (tTG), catalyzing cross‐link formation between protein‐bound glutamine residues and primary amines, with Parkinson's disease‐associated α‐synuclein protein variants at physiologically relevant concentrations. We have, for the...

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Veröffentlicht in:	Protein science 2008-08, Vol.17 (8), p.1395-1402
Hauptverfasser:	Segers‐Nolten, Ine M.J., Wilhelmus, Micha M.M., Veldhuis, Gertjan, van Rooijen, Bart D., Drukarch, Benjamin, Subramaniam, Vinod
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - chemistry alpha-Synuclein - genetics alpha-Synuclein - metabolism atomic force microscopy Circular Dichroism cross‐linking Dimerization Electrophoresis, Polyacrylamide Gel Humans Kinetics Microscopy, Atomic Force Mutation oligomer Parkinson Disease - metabolism Parkinson's disease Protein Binding Surface Plasmon Resonance tissue transglutaminase Transglutaminases - metabolism α‐synuclein
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