Rats that differentially respond to cocaine differ in their dopaminergic storage capacity of the nucleus accumbens

Cocaine (COC) inhibits the re-uptake of dopamine. However, the dopamine response to COC also depends on dopamine inside storage vesicles. The aim of this study was to investigate whether rats that differentially respond to COC differ in their dopaminergic storage capacity of the nucleus accumbens. T...

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Veröffentlicht in:	Journal of neurochemistry 2008-06, Vol.105 (6), p.2122-2133
Hauptverfasser:	Verheij, Michel M.M, de Mulder, Eric L.W, De Leonibus, Elvira, van Loo, Karen M.J, Cools, Alexander R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cocaine Cocaine - pharmacology Dopamine - metabolism dopamine pools Drug addictions Fundamental and applied biological sciences. Psychology individual differences Male Medical sciences Neurology Neurotransmitters Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Original plasmalemmal transporters Rats Rats, Wistar Reserpine - pharmacology Rodents Synaptic Vesicles - drug effects Synaptic Vesicles - metabolism Toxicology Vertebrates: nervous system and sense organs Vesicular Monoamine Transport Proteins - metabolism vesicular transporters
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