Rats that differentially respond to cocaine differ in their dopaminergic storage capacity of the nucleus accumbens
Cocaine (COC) inhibits the re-uptake of dopamine. However, the dopamine response to COC also depends on dopamine inside storage vesicles. The aim of this study was to investigate whether rats that differentially respond to COC differ in their dopaminergic storage capacity of the nucleus accumbens. T...
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| Veröffentlicht in: | Journal of neurochemistry 2008-06, Vol.105 (6), p.2122-2133 |
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| creator | Verheij, Michel M.M de Mulder, Eric L.W De Leonibus, Elvira van Loo, Karen M.J Cools, Alexander R |
| description | Cocaine (COC) inhibits the re-uptake of dopamine. However, the dopamine response to COC also depends on dopamine inside storage vesicles. The aim of this study was to investigate whether rats that differentially respond to COC differ in their dopaminergic storage capacity of the nucleus accumbens. Total and vesicular levels of accumbal dopamine as well as accumbal vesicular monoamine transporter-2 levels were established in high (HR) and low responders (LR) to novelty rats. Moreover, the effects of reserpine (RES) on the COC-induced increase of extracellular accumbal dopamine were investigated. HR displayed higher accumbal levels of total and vesicular dopamine than LR. Moreover, HR displayed more accumbal vesicular monoamine transporters-2 than LR. COC increased extracellular accumbal dopamine more strongly in HR than in LR. A low dose of RES prevented the COC-induced increase of accumbal dopamine in LR, but not in HR. A higher dose of RES was required to inhibit the COC-induced increase of accumbal dopamine in HR. These data demonstrate that HR were marked by a larger accumbal dopaminergic storage pool than LR. It is hypothesized that HR are more sensitive to COC than LR, because COC can release more dopamine from accumbal storage vesicles in HR than in LR. |
| doi_str_mv | 10.1111/j.1471-4159.2008.05323.x |
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However, the dopamine response to COC also depends on dopamine inside storage vesicles. The aim of this study was to investigate whether rats that differentially respond to COC differ in their dopaminergic storage capacity of the nucleus accumbens. Total and vesicular levels of accumbal dopamine as well as accumbal vesicular monoamine transporter-2 levels were established in high (HR) and low responders (LR) to novelty rats. Moreover, the effects of reserpine (RES) on the COC-induced increase of extracellular accumbal dopamine were investigated. HR displayed higher accumbal levels of total and vesicular dopamine than LR. Moreover, HR displayed more accumbal vesicular monoamine transporters-2 than LR. COC increased extracellular accumbal dopamine more strongly in HR than in LR. A low dose of RES prevented the COC-induced increase of accumbal dopamine in LR, but not in HR. A higher dose of RES was required to inhibit the COC-induced increase of accumbal dopamine in HR. These data demonstrate that HR were marked by a larger accumbal dopaminergic storage pool than LR. It is hypothesized that HR are more sensitive to COC than LR, because COC can release more dopamine from accumbal storage vesicles in HR than in LR.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1111/j.1471-4159.2008.05323.x</identifier><identifier>PMID: 18315567</identifier><identifier>CODEN: JONRA9</identifier><language>eng</language><publisher>Oxford, UK: Oxford, UK : Blackwell Publishing Ltd</publisher><subject>Animals ; Biochemistry ; Biological and medical sciences ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Cocaine ; Cocaine - pharmacology ; Dopamine - metabolism ; dopamine pools ; Drug addictions ; Fundamental and applied biological sciences. Psychology ; individual differences ; Male ; Medical sciences ; Neurology ; Neurotransmitters ; Nucleus Accumbens - drug effects ; Nucleus Accumbens - metabolism ; Original ; plasmalemmal transporters ; Rats ; Rats, Wistar ; Reserpine - pharmacology ; Rodents ; Synaptic Vesicles - drug effects ; Synaptic Vesicles - metabolism ; Toxicology ; Vertebrates: nervous system and sense organs ; Vesicular Monoamine Transport Proteins - metabolism ; vesicular transporters</subject><ispartof>Journal of neurochemistry, 2008-06, Vol.105 (6), p.2122-2133</ispartof><rights>2008 The Authors. Journal Compilation © 2008 International Society for Neurochemistry</rights><rights>2008 INIST-CNRS</rights><rights>Journal compilation © 2008 International Society for Neurochemistry</rights><rights>2008 The Authors. Journal compilation © 2008 International Society for Neurochemistry 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5853-a6de2a72f6be603683f311b2835a5a0edad22ab69eba8ca6e816e8846217e74b3</citedby><cites>FETCH-LOGICAL-c5853-a6de2a72f6be603683f311b2835a5a0edad22ab69eba8ca6e816e8846217e74b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-4159.2008.05323.x$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-4159.2008.05323.x$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20405266$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18315567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Verheij, Michel M.M</creatorcontrib><creatorcontrib>de Mulder, Eric L.W</creatorcontrib><creatorcontrib>De Leonibus, Elvira</creatorcontrib><creatorcontrib>van Loo, Karen M.J</creatorcontrib><creatorcontrib>Cools, Alexander R</creatorcontrib><title>Rats that differentially respond to cocaine differ in their dopaminergic storage capacity of the nucleus accumbens</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>Cocaine (COC) inhibits the re-uptake of dopamine. However, the dopamine response to COC also depends on dopamine inside storage vesicles. The aim of this study was to investigate whether rats that differentially respond to COC differ in their dopaminergic storage capacity of the nucleus accumbens. Total and vesicular levels of accumbal dopamine as well as accumbal vesicular monoamine transporter-2 levels were established in high (HR) and low responders (LR) to novelty rats. Moreover, the effects of reserpine (RES) on the COC-induced increase of extracellular accumbal dopamine were investigated. HR displayed higher accumbal levels of total and vesicular dopamine than LR. Moreover, HR displayed more accumbal vesicular monoamine transporters-2 than LR. COC increased extracellular accumbal dopamine more strongly in HR than in LR. A low dose of RES prevented the COC-induced increase of accumbal dopamine in LR, but not in HR. A higher dose of RES was required to inhibit the COC-induced increase of accumbal dopamine in HR. These data demonstrate that HR were marked by a larger accumbal dopaminergic storage pool than LR. It is hypothesized that HR are more sensitive to COC than LR, because COC can release more dopamine from accumbal storage vesicles in HR than in LR.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Cocaine</subject><subject>Cocaine - pharmacology</subject><subject>Dopamine - metabolism</subject><subject>dopamine pools</subject><subject>Drug addictions</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>individual differences</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Neurotransmitters</subject><subject>Nucleus Accumbens - drug effects</subject><subject>Nucleus Accumbens - metabolism</subject><subject>Original</subject><subject>plasmalemmal transporters</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reserpine - pharmacology</subject><subject>Rodents</subject><subject>Synaptic Vesicles - drug effects</subject><subject>Synaptic Vesicles - metabolism</subject><subject>Toxicology</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Vesicular Monoamine Transport Proteins - metabolism</subject><subject>vesicular transporters</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNqNkV2L1DAUhoso7rj6FzQI6lVrctKk6YWCDH6yKKh7HU7TdDZDp5lNWt3596ZOGT8uxEBI4Dzv-XqzjDBasHSebwtWViwvmagLoFQVVHDgxc2tbHUK3M5WlALknJZwlt2LcUspk6Vkd7MzpjgTQlarLHzGMZLxCkfSuq6zwQ6jw74_kGDj3g8tGT0x3qAb7EIQNySBdYG0fo-7FAgbZ0gcfcCNJQb3aNx4IL6bMTJMprdTJGjMtGvsEO9ndzrso32wvOfZ5ZvXX9fv8otPb9-vX13kRijBc5StBaygk42VlEvFO85YA4oLFEhtiy0ANrK2DSqD0iqWriolsMpWZcPPs5fHvPup2dnWpMkC9nof3A7DQXt0-s_I4K70xn_TUNYghUoJni0Jgr-ebBz1zkVj-x4H66eoK16m3QOvE_n0nyRQVQGwMoGP_wK3fgpDWkNipEjugEyQOkIm-BiD7U49M6pn__VWzzbr2WY9-69_-q9vkvTh7zP_Ei6GJ-DJAmA02HcBB-PiiQNaUgFy7uHFkfvuenv47wb0h4_r-Zf0j476Dr3GTUg1Lr8AZZzSmgKtav4DgcDWqA</recordid><startdate>200806</startdate><enddate>200806</enddate><creator>Verheij, Michel M.M</creator><creator>de Mulder, Eric L.W</creator><creator>De Leonibus, Elvira</creator><creator>van Loo, Karen M.J</creator><creator>Cools, Alexander R</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>FBQ</scope><scope>24P</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200806</creationdate><title>Rats that differentially respond to cocaine differ in their dopaminergic storage capacity of the nucleus accumbens</title><author>Verheij, Michel M.M ; de Mulder, Eric L.W ; De Leonibus, Elvira ; van Loo, Karen M.J ; Cools, Alexander R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5853-a6de2a72f6be603683f311b2835a5a0edad22ab69eba8ca6e816e8846217e74b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Cocaine</topic><topic>Cocaine - pharmacology</topic><topic>Dopamine - metabolism</topic><topic>dopamine pools</topic><topic>Drug addictions</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>individual differences</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Neurotransmitters</topic><topic>Nucleus Accumbens - drug effects</topic><topic>Nucleus Accumbens - metabolism</topic><topic>Original</topic><topic>plasmalemmal transporters</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reserpine - pharmacology</topic><topic>Rodents</topic><topic>Synaptic Vesicles - drug effects</topic><topic>Synaptic Vesicles - metabolism</topic><topic>Toxicology</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Vesicular Monoamine Transport Proteins - metabolism</topic><topic>vesicular transporters</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Verheij, Michel M.M</creatorcontrib><creatorcontrib>de Mulder, Eric L.W</creatorcontrib><creatorcontrib>De Leonibus, Elvira</creatorcontrib><creatorcontrib>van Loo, Karen M.J</creatorcontrib><creatorcontrib>Cools, Alexander R</creatorcontrib><collection>AGRIS</collection><collection>Wiley Online Library Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Verheij, Michel M.M</au><au>de Mulder, Eric L.W</au><au>De Leonibus, Elvira</au><au>van Loo, Karen M.J</au><au>Cools, Alexander R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rats that differentially respond to cocaine differ in their dopaminergic storage capacity of the nucleus accumbens</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>2008-06</date><risdate>2008</risdate><volume>105</volume><issue>6</issue><spage>2122</spage><epage>2133</epage><pages>2122-2133</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><abstract>Cocaine (COC) inhibits the re-uptake of dopamine. However, the dopamine response to COC also depends on dopamine inside storage vesicles. The aim of this study was to investigate whether rats that differentially respond to COC differ in their dopaminergic storage capacity of the nucleus accumbens. Total and vesicular levels of accumbal dopamine as well as accumbal vesicular monoamine transporter-2 levels were established in high (HR) and low responders (LR) to novelty rats. Moreover, the effects of reserpine (RES) on the COC-induced increase of extracellular accumbal dopamine were investigated. HR displayed higher accumbal levels of total and vesicular dopamine than LR. Moreover, HR displayed more accumbal vesicular monoamine transporters-2 than LR. COC increased extracellular accumbal dopamine more strongly in HR than in LR. A low dose of RES prevented the COC-induced increase of accumbal dopamine in LR, but not in HR. A higher dose of RES was required to inhibit the COC-induced increase of accumbal dopamine in HR. These data demonstrate that HR were marked by a larger accumbal dopaminergic storage pool than LR. It is hypothesized that HR are more sensitive to COC than LR, because COC can release more dopamine from accumbal storage vesicles in HR than in LR.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>18315567</pmid><doi>10.1111/j.1471-4159.2008.05323.x</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biochemistry Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cocaine Cocaine - pharmacology Dopamine - metabolism dopamine pools Drug addictions Fundamental and applied biological sciences. Psychology individual differences Male Medical sciences Neurology Neurotransmitters Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Original plasmalemmal transporters Rats Rats, Wistar Reserpine - pharmacology Rodents Synaptic Vesicles - drug effects Synaptic Vesicles - metabolism Toxicology Vertebrates: nervous system and sense organs Vesicular Monoamine Transport Proteins - metabolism vesicular transporters |
| title | Rats that differentially respond to cocaine differ in their dopaminergic storage capacity of the nucleus accumbens |
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