Interfering with extracellular matrix degradation to blunt inflammation
Chemoattractant properties of matrix proteins, like collagen and elastin, for neutrophils and monocytes in vitro have long been recognized. This activity often resides in fragments of these proteins. These peptides may play a role in diseases of the lung matrix, such as chronic obstructive pulmonary...
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| Veröffentlicht in: | Current opinion in pharmacology 2008-06, Vol.8 (3), p.242-248 |
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| creator | O’Reilly, Philip J Gaggar, Amit Blalock, J Edwin |
| description | Chemoattractant properties of matrix proteins, like collagen and elastin, for neutrophils and monocytes in vitro have long been recognized. This activity often resides in fragments of these proteins. These peptides may play a role in diseases of the lung matrix, such as chronic obstructive pulmonary disease. Recent advances include the elucidation of the structure of chemotactic collagen fragments and the demonstration that their activity may reside in a structural relatedness to CXC chemokines. Collagen and elastin fragments have been demonstrated to have a role in in vivo lung pathophysiology and have been quantified in patients with chronic lung diseases where they may activate autoimmune pathways. Elucidation of these pathways may provide novel biomarkers and therapeutic targets for chronic lung diseases. |
| doi_str_mv | 10.1016/j.coph.2008.02.003 |
| format | Article |
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Elucidation of these pathways may provide novel biomarkers and therapeutic targets for chronic lung diseases.</description><subject>Animals</subject><subject>Chemokines, CXC - chemistry</subject><subject>Chemotactic Factors - metabolism</subject><subject>Collagen - metabolism</subject><subject>Elastin - metabolism</subject><subject>Extracellular Matrix Proteins - metabolism</subject><subject>Humans</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - metabolism</subject><subject>Internal Medicine</subject><subject>Lung - metabolism</subject><subject>Lung Diseases - drug therapy</subject><subject>Matrix Metalloproteinase 9 - physiology</subject><subject>Medical Education</subject><subject>Oligopeptides - biosynthesis</subject><subject>Oligopeptides - chemistry</subject><subject>Peptide Fragments - metabolism</subject><subject>Peptide Hydrolases - physiology</subject><subject>Pulmonary Disease, Chronic Obstructive - drug therapy</subject><issn>1471-4892</issn><issn>1471-4973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUk1v1DAUjBCIlsIf4IBy4rbhOfb6Q0KVUAWlUiUOwNlynOddL4m92Elp_z0Ou3wegJMtv5nRPM9U1VMCDQHCX-waG_fbpgWQDbQNAL1XnRImyIopQe9_v0vVnlSPct4BkDWl4mF1QiRlXFF-Wl1ehQmTw-TDpv7ip22Nt1MyFodhHkyqRzMlf1v3uEmmN5OPoZ5i3Q1zmGof3GDG8dvr4-qBM0PGJ8fzrPr45vWHi7er63eXVxevrld2LWBaUSR8TZ3hCklHoOWu63u2BibAOTScic6BEL0koqcGHCHcGiGVQspakB09q84Puvu5G7G3GIrbQe-TH02609F4_fsk-K3exBvdMkXYmhWB50eBFD_PmCc9-rysawLGOWtRDHLekn8Cix1FpZT_AxRCcVqA7QFoU8w5ofthm4BeEtU7vSSql0Q1tLokWkjPfl34J-UYYQG8PACwfPuNx6Sz9Rgs9j6hnXQf_d_1z_-g28EHb83wCe8w7-KcQglUE50LQb9fOrVUCiSUPglFvwL-WMh7</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>O’Reilly, Philip J</creator><creator>Gaggar, Amit</creator><creator>Blalock, J Edwin</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080601</creationdate><title>Interfering with extracellular matrix degradation to blunt inflammation</title><author>O’Reilly, Philip J ; Gaggar, Amit ; Blalock, J Edwin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-3e1653fa69e1b1026fbdd450470ffea647bf077d817d3a0f116ca7899e34208b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Chemokines, CXC - chemistry</topic><topic>Chemotactic Factors - metabolism</topic><topic>Collagen - metabolism</topic><topic>Elastin - metabolism</topic><topic>Extracellular Matrix Proteins - metabolism</topic><topic>Humans</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - metabolism</topic><topic>Internal Medicine</topic><topic>Lung - metabolism</topic><topic>Lung Diseases - drug therapy</topic><topic>Matrix Metalloproteinase 9 - physiology</topic><topic>Medical Education</topic><topic>Oligopeptides - biosynthesis</topic><topic>Oligopeptides - chemistry</topic><topic>Peptide Fragments - metabolism</topic><topic>Peptide Hydrolases - physiology</topic><topic>Pulmonary Disease, Chronic Obstructive - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O’Reilly, Philip J</creatorcontrib><creatorcontrib>Gaggar, Amit</creatorcontrib><creatorcontrib>Blalock, J Edwin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current opinion in pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O’Reilly, Philip J</au><au>Gaggar, Amit</au><au>Blalock, J Edwin</au><au>Rogers, D</au><au>Donnelly, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interfering with extracellular matrix degradation to blunt inflammation</atitle><jtitle>Current opinion in pharmacology</jtitle><addtitle>Curr Opin Pharmacol</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>8</volume><issue>3</issue><spage>242</spage><epage>248</epage><pages>242-248</pages><issn>1471-4892</issn><eissn>1471-4973</eissn><abstract>Chemoattractant properties of matrix proteins, like collagen and elastin, for neutrophils and monocytes in vitro have long been recognized. 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| ispartof | Current opinion in pharmacology, 2008-06, Vol.8 (3), p.242-248 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Chemokines, CXC - chemistry Chemotactic Factors - metabolism Collagen - metabolism Elastin - metabolism Extracellular Matrix Proteins - metabolism Humans Inflammation - drug therapy Inflammation - metabolism Internal Medicine Lung - metabolism Lung Diseases - drug therapy Matrix Metalloproteinase 9 - physiology Medical Education Oligopeptides - biosynthesis Oligopeptides - chemistry Peptide Fragments - metabolism Peptide Hydrolases - physiology Pulmonary Disease, Chronic Obstructive - drug therapy |
| title | Interfering with extracellular matrix degradation to blunt inflammation |
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