IL-21 induces in vivo immune activation of NK cells and CD8+ T cells in patients with metastatic melanoma and renal cell carcinoma

Purpose Human interleukin-21 (IL-21) is a class I cytokine previously reported in clinical studies on immune responsive cancers. Here we report the effects of systemic IL-21 therapy on the immune system in two phase 1 trials with this novel cytokine. Experimental design Recombinant IL-21 was adminis...

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Veröffentlicht in:	Cancer Immunology, Immunotherapy Immunotherapy, 2008-10, Vol.57 (10), p.1439-1449
Hauptverfasser:	Frederiksen, Klaus Stensgaard, Lundsgaard, Dorthe, Freeman, Jeremy A., Hughes, Steven D., Holm, Thomas L., Skrumsager, Birte K., Petri, Andreas, Hansen, Lasse T., McArthur, Grant A., Davis, Ian D., Skak, Kresten
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Cancer Research Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - immunology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Dermatology Dose-Response Relationship, Drug Flow Cytometry Gene Expression - drug effects Humans Immunology Immunotherapy Interleukins - administration & dosage Interleukins - adverse effects Kidney Neoplasms - drug therapy Kidney Neoplasms - immunology Kidneys Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Maximum Tolerated Dose Medical sciences Medicine Medicine & Public Health Melanoma - drug therapy Melanoma - immunology Nephrology. Urinary tract diseases Oligonucleotide Array Sequence Analysis Oncology Original Original Article Pharmacology. Drug treatments Phosphorylation Recombinant Proteins - administration & dosage Reverse Transcriptase Polymerase Chain Reaction Skin Neoplasms - drug therapy Skin Neoplasms - immunology STAT3 Transcription Factor - drug effects STAT3 Transcription Factor - metabolism T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology Tumors of the skin and soft tissue. Premalignant lesions Tumors of the urinary system
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