Effect of Clotrimazole on the Pump Cycle of the Na,K-ATPase

The effect of the antimycotic drug clotrimazole (CLT) on the Na,K-ATPase was investigated using fluorescence and electrical measurements. The results obtained by steady-state fluorescence experiments with the electrochromic styryl dye RH421 were combined with those achieved by a pre-steady-state met...

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Veröffentlicht in:	Biophysical journal 2008-08, Vol.95 (4), p.1813-1825
Hauptverfasser:	Bartolommei, Gianluca, Devaux, Nadège, Tadini-Buoninsegni, Francesco, Moncelli, MariaRosa, Apell, Hans-Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Infective Agents, Local - administration & dosage Binding Biological Clocks - drug effects Biological Clocks - physiology Biophysics Cell Membrane - drug effects Cell Membrane - physiology Channels, Receptors, and Electrical Signaling Clotrimazole - administration & dosage Electrical measurement Enzymes Fluorescence Medulla Oblongata - drug effects Medulla Oblongata - enzymology Membranes Phosphorylation Potassium Proteins Pumps Rabbits Sodium Sodium-Potassium-Exchanging ATPase - drug effects Sodium-Potassium-Exchanging ATPase - metabolism Transport
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