Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?

Melatonin is a neurohormone that has been claimed to be involved in a wide range of physiological functions. Nevertheless, for most of its effects, the mechanism of action is not really known. In mammals, two melatonin receptors, MT1 and MT2, have been cloned. They belong to the G‐protein‐coupled re...

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Veröffentlicht in:	British journal of pharmacology 2008-07, Vol.154 (6), p.1182-1195
Hauptverfasser:	Jockers, R, Maurice, P, Boutin, J A, Delagrange, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites - drug effects Biological and medical sciences circadian clock circadian rhythm Dimerization GPR50 Humans Life Sciences Medical sciences melatonin MRR MT1 MT2 MT3 Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Pharmacology. Drug treatments quinone reductase 2 Receptor, Melatonin, MT1 - drug effects Receptor, Melatonin, MT1 - metabolism Receptor, Melatonin, MT2 - drug effects Receptor, Melatonin, MT2 - metabolism Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - physiology Receptors, Melatonin - drug effects Receptors, Melatonin - metabolism Receptors, Melatonin - physiology Reviews Signal Transduction - drug effects Signal Transduction - physiology Tissue Distribution
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