Effects of salbutamol on exhaled breath condensate biomarkers in acute lung injury: prospective analysis
The benefits of beta-adrenergic stimulation have been described in acute lung injury (ALI), but there is still no evidence of its anti-inflammatory effect in these patients. Biomarkers in exhaled breath condensate (EBC) were used to study the effects of salbutamol on lung inflammation in mechanicall...
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| description | The benefits of beta-adrenergic stimulation have been described in acute lung injury (ALI), but there is still no evidence of its anti-inflammatory effect in these patients. Biomarkers in exhaled breath condensate (EBC) were used to study the effects of salbutamol on lung inflammation in mechanically ventilated patients with ALI.
EBC was collected before and 30 minutes after administration of inhaled salbutamol (800 microg). The following parameters were measured in the samples: volume obtained, conductivity, pH after helium deaeration, and concentration of nitrites, nitrates and 8-isoprostane. The leukotriene B4 concentration was measured after sample lyophilization and reconstitution. Results are expressed as the median (interquartile range).
EBC was obtained from six ALI patients, with a median age of 56 (46 to 76) years. At the time of EBC collection, the Lung Injury Score was 3 (2.3 to 3.1) and the PaO2/FIO2 ratio was 133 (96 to 211) mmHg. A significant increase in deaerated EBC pH was observed after salbutamol administration (7.66 (7.58 to 7.75) versus 7.83 (7.67 to 7.91), P = 0.028). Trends toward decreased nitrosative species (18.81 (13.33 to 49.44) microM versus 21.21 (8.07 to 29.83) microM, P = 0.173) and decreased 8-isoprostane concentration (11.64 (7.17 to 17.13) pg/ml versus 6.55 (4.03 to 9.99) pg/ml, P = 0.068) were detected. No changes in leukotriene B4 concentration were found (1.58 (0.47 to 3.57) pg/ml versus 2.06 (1.01 to 3.01) pg/ml, P = 0.753).
EBC analysis is a noninvasive technique that can be used to monitor ventilated patients. In EBC from a small cohort of patients with ALI, inhaled salbutamol significantly decreased airspace acidosis, a marker of inflammation, and was associated with a trend toward decreased markers of nitrosative and oxidative stress. |
| doi_str_mv | 10.1186/cc6911 |
| format | Article |
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EBC was collected before and 30 minutes after administration of inhaled salbutamol (800 microg). The following parameters were measured in the samples: volume obtained, conductivity, pH after helium deaeration, and concentration of nitrites, nitrates and 8-isoprostane. The leukotriene B4 concentration was measured after sample lyophilization and reconstitution. Results are expressed as the median (interquartile range).
EBC was obtained from six ALI patients, with a median age of 56 (46 to 76) years. At the time of EBC collection, the Lung Injury Score was 3 (2.3 to 3.1) and the PaO2/FIO2 ratio was 133 (96 to 211) mmHg. A significant increase in deaerated EBC pH was observed after salbutamol administration (7.66 (7.58 to 7.75) versus 7.83 (7.67 to 7.91), P = 0.028). Trends toward decreased nitrosative species (18.81 (13.33 to 49.44) microM versus 21.21 (8.07 to 29.83) microM, P = 0.173) and decreased 8-isoprostane concentration (11.64 (7.17 to 17.13) pg/ml versus 6.55 (4.03 to 9.99) pg/ml, P = 0.068) were detected. No changes in leukotriene B4 concentration were found (1.58 (0.47 to 3.57) pg/ml versus 2.06 (1.01 to 3.01) pg/ml, P = 0.753).
EBC analysis is a noninvasive technique that can be used to monitor ventilated patients. In EBC from a small cohort of patients with ALI, inhaled salbutamol significantly decreased airspace acidosis, a marker of inflammation, and was associated with a trend toward decreased markers of nitrosative and oxidative stress.</description><identifier>ISSN: 1364-8535</identifier><identifier>EISSN: 1466-609X</identifier><identifier>EISSN: 1364-8535</identifier><identifier>DOI: 10.1186/cc6911</identifier><identifier>PMID: 18513388</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Acute respiratory distress syndrome ; Adrenergic beta-Agonists - therapeutic use ; Aged ; Albuterol ; Albuterol - therapeutic use ; Biological markers ; Biomarkers - metabolism ; Breath Tests ; Care and treatment ; Diagnosis ; Dinoprost - analogs & derivatives ; Dinoprost - metabolism ; Dosage and administration ; Exhalation ; Female ; Health aspects ; Humans ; Hydrogen-Ion Concentration ; Leukotriene B4 - metabolism ; Male ; Metered Dose Inhalers ; Middle Aged ; Nitrates - metabolism ; Nitrites - metabolism ; Prospective Studies ; Pulmonary Gas Exchange ; Respiration, Artificial ; Respiratory Distress Syndrome, Adult - metabolism ; Respiratory Distress Syndrome, Adult - therapy ; Severity of Illness Index</subject><ispartof>Critical care (London, England), 2008-01, Vol.12 (3), p.R72-R72, Article R72</ispartof><rights>COPYRIGHT 2008 BioMed Central Ltd.</rights><rights>Copyright National Library of Medicine - MEDLINE Abstracts 2008</rights><rights>Copyright © 2008 Roca et al.; licensee BioMed Central Ltd. 2008 Roca et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b480t-8eb21925ce6a37609bf4763cfc00386abc943b8ea44c10c5ba0c0f78d36999013</citedby><cites>FETCH-LOGICAL-b480t-8eb21925ce6a37609bf4763cfc00386abc943b8ea44c10c5ba0c0f78d36999013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481464/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481464/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18513388$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roca, Oriol</creatorcontrib><creatorcontrib>Gómez-Ollés, Susana</creatorcontrib><creatorcontrib>Cruz, Maria-Jesús</creatorcontrib><creatorcontrib>Muñoz, Xavier</creatorcontrib><creatorcontrib>Griffiths, Mark J D</creatorcontrib><creatorcontrib>Masclans, Joan R</creatorcontrib><title>Effects of salbutamol on exhaled breath condensate biomarkers in acute lung injury: prospective analysis</title><title>Critical care (London, England)</title><addtitle>Crit Care</addtitle><description>The benefits of beta-adrenergic stimulation have been described in acute lung injury (ALI), but there is still no evidence of its anti-inflammatory effect in these patients. Biomarkers in exhaled breath condensate (EBC) were used to study the effects of salbutamol on lung inflammation in mechanically ventilated patients with ALI.
EBC was collected before and 30 minutes after administration of inhaled salbutamol (800 microg). The following parameters were measured in the samples: volume obtained, conductivity, pH after helium deaeration, and concentration of nitrites, nitrates and 8-isoprostane. The leukotriene B4 concentration was measured after sample lyophilization and reconstitution. Results are expressed as the median (interquartile range).
EBC was obtained from six ALI patients, with a median age of 56 (46 to 76) years. At the time of EBC collection, the Lung Injury Score was 3 (2.3 to 3.1) and the PaO2/FIO2 ratio was 133 (96 to 211) mmHg. A significant increase in deaerated EBC pH was observed after salbutamol administration (7.66 (7.58 to 7.75) versus 7.83 (7.67 to 7.91), P = 0.028). Trends toward decreased nitrosative species (18.81 (13.33 to 49.44) microM versus 21.21 (8.07 to 29.83) microM, P = 0.173) and decreased 8-isoprostane concentration (11.64 (7.17 to 17.13) pg/ml versus 6.55 (4.03 to 9.99) pg/ml, P = 0.068) were detected. No changes in leukotriene B4 concentration were found (1.58 (0.47 to 3.57) pg/ml versus 2.06 (1.01 to 3.01) pg/ml, P = 0.753).
EBC analysis is a noninvasive technique that can be used to monitor ventilated patients. In EBC from a small cohort of patients with ALI, inhaled salbutamol significantly decreased airspace acidosis, a marker of inflammation, and was associated with a trend toward decreased markers of nitrosative and oxidative stress.</description><subject>Acute respiratory distress syndrome</subject><subject>Adrenergic beta-Agonists - therapeutic use</subject><subject>Aged</subject><subject>Albuterol</subject><subject>Albuterol - therapeutic use</subject><subject>Biological markers</subject><subject>Biomarkers - metabolism</subject><subject>Breath Tests</subject><subject>Care and treatment</subject><subject>Diagnosis</subject><subject>Dinoprost - analogs & derivatives</subject><subject>Dinoprost - metabolism</subject><subject>Dosage and administration</subject><subject>Exhalation</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Leukotriene B4 - metabolism</subject><subject>Male</subject><subject>Metered Dose Inhalers</subject><subject>Middle Aged</subject><subject>Nitrates - metabolism</subject><subject>Nitrites - metabolism</subject><subject>Prospective Studies</subject><subject>Pulmonary Gas Exchange</subject><subject>Respiration, Artificial</subject><subject>Respiratory Distress Syndrome, Adult - metabolism</subject><subject>Respiratory Distress Syndrome, Adult - therapy</subject><subject>Severity of Illness Index</subject><issn>1364-8535</issn><issn>1466-609X</issn><issn>1364-8535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptUk2PFCEQJUbjrqv-BEM8eOsVBpoGDyabzfqRbOJFE28E6GKGkYYRujfOv5fNTBzXGA5A1atXVa8KoZeUXFIqxVvnhKL0ETqnXIhOEPX9cXszwTvZs_4MPat1SwgdpGBP0RmVPWVMynO0ufEe3Fxx9riaaJfZTDninDD82pgII7YFzLzBLqcRUjUzYBvyZMoPKBWHhI1bmi0uad1-26Xs3-FdyXXXWMMdYJNM3NdQn6Mn3sQKL473Bfr24ebr9afu9svHz9dXt53lksydBLuiatU7EIYNrQ_r-SCY844QJoWxTnFmJRjOHSWut4Y44gc5MqGUIpRdoPcH3t1iJxgdpLmYqHcltJr3OpugH3pS2Oh1vtMrLpt2vBGoA8F9m_8neOhxedIH-Vvsm2Pykn8uUGc9heogRpMgL1ULxThndNWAr_8BbvNSmlRVU9VzweQgG-jyAFq3QeiQfG75XDsjTKHNA3xo9isqCVVEUX5K79oAagH_p2pK9P2anOp89bdIJ9hxL9hvE_C7GQ</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Roca, Oriol</creator><creator>Gómez-Ollés, Susana</creator><creator>Cruz, Maria-Jesús</creator><creator>Muñoz, Xavier</creator><creator>Griffiths, Mark J D</creator><creator>Masclans, Joan R</creator><general>BioMed Central Ltd</general><general>National Library of Medicine - MEDLINE Abstracts</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080101</creationdate><title>Effects of salbutamol on exhaled breath condensate biomarkers in acute lung injury: prospective analysis</title><author>Roca, Oriol ; Gómez-Ollés, Susana ; Cruz, Maria-Jesús ; Muñoz, Xavier ; Griffiths, Mark J D ; Masclans, Joan R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b480t-8eb21925ce6a37609bf4763cfc00386abc943b8ea44c10c5ba0c0f78d36999013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acute respiratory distress syndrome</topic><topic>Adrenergic beta-Agonists - therapeutic use</topic><topic>Aged</topic><topic>Albuterol</topic><topic>Albuterol - therapeutic use</topic><topic>Biological markers</topic><topic>Biomarkers - metabolism</topic><topic>Breath Tests</topic><topic>Care and treatment</topic><topic>Diagnosis</topic><topic>Dinoprost - analogs & derivatives</topic><topic>Dinoprost - metabolism</topic><topic>Dosage and administration</topic><topic>Exhalation</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Leukotriene B4 - metabolism</topic><topic>Male</topic><topic>Metered Dose Inhalers</topic><topic>Middle Aged</topic><topic>Nitrates - metabolism</topic><topic>Nitrites - metabolism</topic><topic>Prospective Studies</topic><topic>Pulmonary Gas Exchange</topic><topic>Respiration, Artificial</topic><topic>Respiratory Distress Syndrome, Adult - metabolism</topic><topic>Respiratory Distress Syndrome, Adult - therapy</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roca, Oriol</creatorcontrib><creatorcontrib>Gómez-Ollés, Susana</creatorcontrib><creatorcontrib>Cruz, Maria-Jesús</creatorcontrib><creatorcontrib>Muñoz, Xavier</creatorcontrib><creatorcontrib>Griffiths, Mark J D</creatorcontrib><creatorcontrib>Masclans, Joan R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Critical care (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roca, Oriol</au><au>Gómez-Ollés, Susana</au><au>Cruz, Maria-Jesús</au><au>Muñoz, Xavier</au><au>Griffiths, Mark J D</au><au>Masclans, Joan R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of salbutamol on exhaled breath condensate biomarkers in acute lung injury: prospective analysis</atitle><jtitle>Critical care (London, England)</jtitle><addtitle>Crit Care</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>12</volume><issue>3</issue><spage>R72</spage><epage>R72</epage><pages>R72-R72</pages><artnum>R72</artnum><issn>1364-8535</issn><eissn>1466-609X</eissn><eissn>1364-8535</eissn><abstract>The benefits of beta-adrenergic stimulation have been described in acute lung injury (ALI), but there is still no evidence of its anti-inflammatory effect in these patients. Biomarkers in exhaled breath condensate (EBC) were used to study the effects of salbutamol on lung inflammation in mechanically ventilated patients with ALI.
EBC was collected before and 30 minutes after administration of inhaled salbutamol (800 microg). The following parameters were measured in the samples: volume obtained, conductivity, pH after helium deaeration, and concentration of nitrites, nitrates and 8-isoprostane. The leukotriene B4 concentration was measured after sample lyophilization and reconstitution. Results are expressed as the median (interquartile range).
EBC was obtained from six ALI patients, with a median age of 56 (46 to 76) years. At the time of EBC collection, the Lung Injury Score was 3 (2.3 to 3.1) and the PaO2/FIO2 ratio was 133 (96 to 211) mmHg. A significant increase in deaerated EBC pH was observed after salbutamol administration (7.66 (7.58 to 7.75) versus 7.83 (7.67 to 7.91), P = 0.028). Trends toward decreased nitrosative species (18.81 (13.33 to 49.44) microM versus 21.21 (8.07 to 29.83) microM, P = 0.173) and decreased 8-isoprostane concentration (11.64 (7.17 to 17.13) pg/ml versus 6.55 (4.03 to 9.99) pg/ml, P = 0.068) were detected. No changes in leukotriene B4 concentration were found (1.58 (0.47 to 3.57) pg/ml versus 2.06 (1.01 to 3.01) pg/ml, P = 0.753).
EBC analysis is a noninvasive technique that can be used to monitor ventilated patients. In EBC from a small cohort of patients with ALI, inhaled salbutamol significantly decreased airspace acidosis, a marker of inflammation, and was associated with a trend toward decreased markers of nitrosative and oxidative stress.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>18513388</pmid><doi>10.1186/cc6911</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings; Springer Nature OA Free Journals |
| subjects | Acute respiratory distress syndrome Adrenergic beta-Agonists - therapeutic use Aged Albuterol Albuterol - therapeutic use Biological markers Biomarkers - metabolism Breath Tests Care and treatment Diagnosis Dinoprost - analogs & derivatives Dinoprost - metabolism Dosage and administration Exhalation Female Health aspects Humans Hydrogen-Ion Concentration Leukotriene B4 - metabolism Male Metered Dose Inhalers Middle Aged Nitrates - metabolism Nitrites - metabolism Prospective Studies Pulmonary Gas Exchange Respiration, Artificial Respiratory Distress Syndrome, Adult - metabolism Respiratory Distress Syndrome, Adult - therapy Severity of Illness Index |
| title | Effects of salbutamol on exhaled breath condensate biomarkers in acute lung injury: prospective analysis |
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