UGT1A128 genotype and irinotecan dosage in patients with metastatic colorectal cancer: a Dutch Colorectal Cancer Group study

The aim of the study was to investigate the associations between UGT1A1 * 28 genotype and (1) response rates, (2) febrile neutropenia and (3) dose intensity in patients with metastatic colorectal cancer treated with irinotecan. UGT1A1 * 28 genotype was determined in 218 patients receiving irinotecan...

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Veröffentlicht in:	British journal of cancer 2008-07, Vol.99 (2), p.275-282
Hauptverfasser:	Kweekel, D M, Gelderblom, H, Van der Straaten, T, Antonini, N F, Punt, C J A, Guchelaar, H-J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Biomedical and Life Sciences Biomedicine Camptothecin - administration & dosage Camptothecin - adverse effects Camptothecin - analogs & derivatives Cancer Research Capecitabine Clinical Study Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - enzymology Colorectal Neoplasms - genetics Deoxycytidine - administration & dosage Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Dose-Response Relationship, Drug Drug Resistance Epidemiology Fever - etiology Fluorouracil - administration & dosage Fluorouracil - adverse effects Fluorouracil - analogs & derivatives Genotype Glucuronosyltransferase - genetics Humans Molecular Medicine Neoplasm Metastasis Neutropenia - chemically induced Neutropenia - complications Oncology Organoplatinum Compounds - administration & dosage Organoplatinum Compounds - adverse effects
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