Muscle-like nicotinic receptor accessory molecules in sensory hair cells of the inner ear

Nothing is known about the regulation of nicotinic acetylcholine receptors (nAChRs) in hair cells of the inner ear. MuSK, rapsyn and RIC-3 are accessory molecules associated with muscle and brain nAChR function. We demonstrate that these accessory molecules are expressed in the inner ear raising the...

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Veröffentlicht in:	Molecular and cellular neuroscience 2008-06, Vol.38 (2), p.153-169
Hauptverfasser:	Osman, Abdullah A., Schrader, Angela D., Hawkes, Aubrey J., Akil, Omar, Bergeron, Adam, Lustig, Lawrence R., Simmons, Dwayne D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bungarotoxins - pharmacology Calcium - metabolism Cholinergic synapse Female Hair Cells, Auditory, Inner - cytology Hair Cells, Auditory, Inner - metabolism Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kidney - cytology LLC-PK1 Cells Male Mice Mice, Inbred C57BL Muscle Proteins - metabolism Peripheral auditory system Pregnancy Rats Rats, Sprague-Dawley Receptor assembly and clustering Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Receptors, Cholinergic - genetics Receptors, Cholinergic - metabolism Receptors, Nicotinic - genetics Receptors, Nicotinic - metabolism RNA, Messenger - metabolism Swine Synapses - metabolism Synaptogenesis Transfection
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