Mobility of TOAC spin-labelled peptides binding to the Src SH3 domain studied by paramagnetic NMR

Paramagnetic relaxation enhancement provides a tool for studying the dynamics as well as the structure of macromolecular complexes. The application of side-chain coupled spin-labels is limited by the mobility of the free radical. The cyclic, rigid amino acid spin-label TOAC (2,2,6,6-Tetramethylpiper...

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Veröffentlicht in:	Journal of biomolecular NMR 2008-07, Vol.41 (3), p.157-167
Hauptverfasser:	Lindfors, Hanna E, de Koning, Peter E, Drijfhout, Jan Wouter, Venezia, Brigida, Ubbink, Marcellus
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Biochemistry Biological and Medical Physics Biophysics Carboxylic acids Cyclic N-Oxides - chemistry Free radicals Kinases Magnetics Mice Molecular Structure Nuclear Magnetic Resonance, Biomolecular Peptides Peptides - chemistry Peptides - genetics Peptides - metabolism Physics Physics and Astronomy Protein Structure, Tertiary Proteins Spectroscopy/Spectrometry Spin Labels src Homology Domains
Online-Zugang:	Volltext
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